GluR-δ2 Antibody (D-9): sc-393437

GluR-δ2 Antibody (D-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects GluR-δ2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GluR-δ2 antibody (D-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GluR-δ2, also known as GRID2, is a crucial component of the ionotropic glutamate receptor family, which mediates the majority of excitatory neurotransmission in the central nervous system. GluR-δ2 is primarily located at the postsynaptic membrane of neurons, where GluR-δ2 plays a vital role in synaptic transmission and plasticity. Proper localization of GluR-δ2 is essential for the formation and maintenance of synapses, influencing processes such as learning and memory. Mutations in the gene encoding GluR-δ2 can lead to significant neurological disorders, including the Lurcher phenotype in mice, highlighting GluR-δ2′s importance in neural development and function. The human gene for GluR-δ2 is located on chromosome 4q22, and GluR-δ2′s interactions with other glutamate receptor subunits underscore GluR-δ2′s role in excitatory signaling pathways.

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GluR-δ2 Antibody (D-9) References:

1. Fast and slow components of unitary EPSCs on stellate cells elicited by focal stimulation in slices of rat visual cortex.  |  Stern, P., et al. 1992. J Physiol. 449: 247-78. PMID: 1326045
2. Molecular diversity of glutamate receptors and implications for brain function.  |  Nakanishi, S. 1992. Science. 258: 597-603. PMID: 1329206
3. Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRdelta2.  |  Kakegawa, W., et al. 2008. J Neurosci. 28: 1460-8. PMID: 18256267
4. Cbln1 accumulates and colocalizes with Cbln3 and GluRdelta2 at parallel fiber-Purkinje cell synapses in the mouse cerebellum.  |  Miura, E., et al. 2009. Eur J Neurosci. 29: 693-706. PMID: 19250438
5. The N-terminal domain of GluD2 (GluRdelta2) recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo.  |  Kakegawa, W., et al. 2009. J Neurosci. 29: 5738-48. PMID: 19420242
6. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death.  |  Choi, DW. and Rothman, SM. 1990. Annu Rev Neurosci. 13: 171-82. PMID: 1970230
7. Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem.  |  Watanabe, M., et al. 1994. J Comp Neurol. 343: 520-31. PMID: 7518475
8. Cloned glutamate receptors.  |  Hollmann, M. and Heinemann, S. 1994. Annu Rev Neurosci. 17: 31-108. PMID: 8210177
9. A synaptic model of memory: long-term potentiation in the hippocampus.  |  Bliss, TV. and Collingridge, GL. 1993. Nature. 361: 31-9. PMID: 8421494
10. Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor gene.  |  Zuo, J., et al. 1997. Nature. 388: 769-73. PMID: 9285588
11. Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate.  |  Schiffer, HH., et al. 1997. Neuron. 19: 1141-6. PMID: 9390526
12. The human glutamate receptor delta 2 gene (GRID2) maps to chromosome 4q22.  |  Hu, W., et al. 1998. Genomics. 47: 143-5. PMID: 9465309

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GluR-δ2 Antibody (D-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GluR-δ2 Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GluR-δ2 Antibody (D-9) Specifications

Alternate Product Name: Glutamate receptor Delta type 2

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 972-1005

Epitope Target: GluR-δ2

Epitope Species: human

Product Reactivity/Detection: GluR-δ2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GluR-δ2 Antibody (D-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin