GluR-4 Antibody (F-9): sc-271894

GluR-4 Antibody (F-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects GluR-4 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-GluR-4 antibody (F-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GluR-4, also known as GRIA4, is a critical component of the AMPA receptor family, which mediates fast excitatory neurotransmission in the central nervous system. GluR-4 is primarily located in the postsynaptic membrane of neurons, where GluR-4 plays a vital role in synaptic plasticity, a mechanism essential for learning and memory. Proper functioning of GluR-4 is crucial, as alterations in GluR-4 expression or activity can lead to various neurological disorders, including epilepsy and schizophrenia. GluR-4 interacts with other proteins such as PSD-95, which is involved in the clustering of AMPA receptors at synapses, further emphasizing GluR-4′s importance in maintaining synaptic integrity and function. Using GluR-4 monoclonal antibody (F-9) in research can provide valuable insights into the dynamics of excitatory neurotransmission and its implications in neurobiology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GluR-4 Antibody (F-9) References:

1. Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation.  |  Correia, SS., et al. 2003. J Biol Chem. 278: 6307-13. PMID: 12471040
2. Fast and slow components of unitary EPSCs on stellate cells elicited by focal stimulation in slices of rat visual cortex.  |  Stern, P., et al. 1992. J Physiol. 449: 247-78. PMID: 1326045
3. Molecular diversity of glutamate receptors and implications for brain function.  |  Nakanishi, S. 1992. Science. 258: 597-603. PMID: 1329206
4. Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor.  |  Santos, AE., et al. 2006. Cell Death Differ. 13: 652-60. PMID: 16282983
5. PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression.  |  Gomes, AR., et al. 2007. Traffic. 8: 259-69. PMID: 17233759
6. Interaction of the N-terminal domain of the AMPA receptor GluR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment.  |  Sia, GM., et al. 2007. Neuron. 55: 87-102. PMID: 17610819
7. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death.  |  Choi, DW. and Rothman, SM. 1990. Annu Rev Neurosci. 13: 171-82. PMID: 1970230
8. Association of SLC12A1 and GLUR4 Ion Transporters with Neoadjuvant Chemoresistance in Luminal Locally Advanced Breast Cancer.  |  Justo-Garrido, M., et al. 2023. Int J Mol Sci. 24: PMID: 38003293
9. Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem.  |  Watanabe, M., et al. 1994. J Comp Neurol. 343: 520-31. PMID: 7518475
10. Cloned glutamate receptors.  |  Hollmann, M. and Heinemann, S. 1994. Annu Rev Neurosci. 17: 31-108. PMID: 8210177
11. A synaptic model of memory: long-term potentiation in the hippocampus.  |  Bliss, TV. and Collingridge, GL. 1993. Nature. 361: 31-9. PMID: 8421494
12. Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate.  |  Schiffer, HH., et al. 1997. Neuron. 19: 1141-6. PMID: 9390526

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GluR-4 Antibody (F-9) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-GluR-4 Antibody (F-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GluR-4 Antibody (F-9) Specifications

Alternate Product Name: Glutamate receptor AMPA type 4

Product Clone Name: F-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 31-75

Epitope Target: GluR-4

Epitope Species: human

Product Reactivity/Detection: GluR-4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for GluR-4 Antibody (F-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin