GluR-2 Antibody (7G6): sc-517265
- GluR-2 Antibody (7G6) is a mouse monoclonal IgG1 κ GluR-2 antibody, cited in 20 publications, provided at 200 µg/ml
- raised against amino acids 652-807 of GluR-2 of human origin
- GluR-2 Antibody (7G6) is recommended for detection of GluR-2 of mouse, rat and human origin by WB, IP and FCM
- Anti-GluR-2 Antibody (7G6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GluR-2 Antibody (7G6) for WB applications. These reagents are now offered in bundles with GluR-2 Antibody (7G6) (see ordering information below).
GluR-2 Antibody (7G6) is a mouse monoclonal IgG1 kappa light chain antibody that detects GluR-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Anti-GluR-2 antibody (7G6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GluR-2, also known as GRIA2, is a critical component of the AMPA receptor complex, which mediates fast excitatory neurotransmission in the central nervous system. GluR-2 is primarily located in the postsynaptic membrane of neurons, where GluR-2 plays a vital role in synaptic plasticity, a fundamental mechanism underlying learning and memory. Proper functioning of GluR-2 is essential for maintaining synaptic strength and facilitating communication between neurons. Alterations in GluR-2 expression or function have been implicated in various neurological disorders, including epilepsy, schizophrenia, and neurodegenerative diseases, highlighting GluR-2′s significance in both normal brain function and disease pathology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GluR-2 Antibody (7G6) References:
- Fast and slow components of unitary EPSCs on stellate cells elicited by focal stimulation in slices of rat visual cortex. | Stern, P., et al. 1992. J Physiol. 449: 247-78. PMID: 1326045
- Molecular diversity of glutamate receptors and implications for brain function. | Nakanishi, S. 1992. Science. 258: 597-603. PMID: 1329206
- The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death. | Choi, DW. and Rothman, SM. 1990. Annu Rev Neurosci. 13: 171-82. PMID: 1970230
- Effect of mismatch on binding of ADAR2/GluR-2 pre-mRNA complex. | Yang, J., et al. 2015. J Mol Model. 21: 222. PMID: 26252972
- Acute rosmarinic acid treatment enhances long-term potentiation, BDNF and GluR-2 protein expression, and cell survival rate against scopolamine challenge in rat organotypic hippocampal slice cultures. | Hwang, ES., et al. 2016. Biochem Biophys Res Commun. 475: 44-50. PMID: 27163641
- [Effect of Catgut Implantation on Spatial Learning-memory Ability, Expression of Hippocampal Protein Kinase C Interacting Protein 1 and GluR 2 and Ca2+ Content in Rats with Chronic Ischemic Cognitive Impairment]. | Li, S., et al. 2018. Zhen Ci Yan Jiu. 43: 347-52. PMID: 30091539
- Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem. | Watanabe, M., et al. 1994. J Comp Neurol. 343: 520-31. PMID: 7518475
- Microzonal decreases in the immunostaining for non-NMDA ionotropic excitatory amino acid receptor subunits GluR 2/3 and GluR 5/6/7 in the human epileptogenic neocortex. | DeFelipe, J., et al. 1994. Brain Res. 657: 150-8. PMID: 7820613
- Cloned glutamate receptors. | Hollmann, M. and Heinemann, S. 1994. Annu Rev Neurosci. 17: 31-108. PMID: 8210177
- A synaptic model of memory: long-term potentiation in the hippocampus. | Bliss, TV. and Collingridge, GL. 1993. Nature. 361: 31-9. PMID: 8421494
- Distribution of glutamate receptors GluR 2/3 and NR1 in the developing rat cerebellum. | Hafidi, A. and Hillman, DE. 1997. Neuroscience. 81: 427-36. PMID: 9300432
- Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate. | Schiffer, HH., et al. 1997. Neuron. 19: 1141-6. PMID: 9390526
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GluR-2 Antibody (7G6) | sc-517265 | 200 µg/ml | $322.00 | |||
GluR-2 Antibody (7G6): m-IgG Fc BP-HRP Bundle | sc-531573 | 200 µg Ab; 10 µg BP | $361.00 | |||
GluR-2 Antibody (7G6): m-IgGκ BP-HRP Bundle | sc-525301 | 200 µg Ab, 40 µg BP | $361.00 | |||
GluR-2 Antibody (7G6): m-IgG1 BP-HRP Bundle | sc-544633 | 200 µg Ab; 20 µg BP | $361.00 | |||
GluR-2 Antibody (7G6) AC | sc-517265 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GluR-2 Antibody (7G6) HRP | sc-517265 HRP | 200 µg/ml | $322.00 | |||
GluR-2 Antibody (7G6) FITC | sc-517265 FITC | 200 µg/ml | $336.00 | |||
GluR-2 Antibody (7G6) PE | sc-517265 PE | 200 µg/ml | $349.00 | |||
GluR-2 Antibody (7G6) Alexa Fluor® 488 | sc-517265 AF488 | 200 µg/ml | $364.00 | |||
GluR-2 Antibody (7G6) Alexa Fluor® 546 | sc-517265 AF546 | 200 µg/ml | $364.00 | |||
GluR-2 Antibody (7G6) Alexa Fluor® 594 | sc-517265 AF594 | 200 µg/ml | $364.00 | |||
GluR-2 Antibody (7G6) Alexa Fluor® 647 | sc-517265 AF647 | 200 µg/ml | $364.00 | |||
GluR-2 Antibody (7G6) Alexa Fluor® 680 | sc-517265 AF680 | 200 µg/ml | $364.00 | |||
GluR-2 Antibody (7G6) Alexa Fluor® 790 | sc-517265 AF790 | 200 µg/ml | $364.00 |