GLTP Antibody (D-9): sc-514388

GLTP Antibody (D-9) is a mouse monoclonal IgG1 antibody that detects glycolipid transfer protein (GLTP) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GLTP is a 209 amino acid protein that plays a crucial role in the transfer of glycosphingolipids between cellular membranes, a process essential for maintaining lipid homeostasis and cellular signaling. The unique GLTP fold allows GLTP to facilitate the intermembrane transfer of various glycosphingolipids, while notably excluding phospholipids, thereby highlighting a specialized function in lipid metabolism. This specificity is vital for cellular processes, as glycosphingolipids are important components of cell membranes and are involved in cell recognition, signaling, and the modulation of membrane fluidity. GLTP is highly conserved across mammalian species and is predominantly localized in the cytoplasm, where GLTP exists as a monomer. The gene encoding GLTP is located on human chromosome 12q24.11 and mouse chromosome 5 F, and GLTP is expressed in various cell types, including fibroblasts and several cancer cell lines, underscoring potential relevance in both normal physiology and disease states. Anti-GLTP antibody (D-9) provides a reliable tool for researchers investigating the role of glycolipid transfer in cellular functions and disease mechanisms.

The preferred GLTP antibody is GLTP Antibody (C-3): sc-514289.