Gl Syn Antibody (F-4): sc-398034
- Gl Syn Antibody (F-4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 281-310 near the C-terminus of Gl Syn of human origin
- recommended for detection of Gl Syn of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Gl Syn Antibody (F-4) for WB applications. These reagents are now offered in bundles with Gl Syn Antibody (F-4) (see ordering information below).
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Gl Syn Antibody (F-4) is a mouse monoclonal IgG1 antibody that detects glutamine synthetase (Gl Syn) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Gl Syn antibody (F-4) recognizes glutamine synthetase, an essential enzyme that forms a homooctamer and catalyzes the conversion of glutamic acid to glutamine, a critical process for maintaining nitrogen balance in the brain and other tissues. Gl Syn (F-4) antibody is predominantly detected in astrocytes, where glutamine synthetase plays a vital role in neurotransmitter metabolism, particularly in the detoxification of excess glutamate, thereby protecting neurons from excitotoxicity. The induction of glutamine synthetase expression upon astrocyte-neuron contact highlights glutamine synthetase′s importance in neuroprotection and cellular communication within the central nervous system. Additionally, glutamine synthetase is present in the liver, where glutamine synthetase contributes to nitrogen homeostasis, and glutamine synthetase overexpression has been implicated in primary liver cancers, suggesting a potential role in hepatocyte transformation and tumor progression. Anti-Gl Syn antibody (F-4) versatility in various applications makes Gl Syn (F-4) monoclonal antibody an invaluable tool for researchers studying the physiological and pathological roles of glutamine synthetase in different biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gl Syn Antibody (F-4) | sc-398034 | 200 µg/ml | $322.00 | |||
Gl Syn Antibody (F-4): m-IgG Fc BP-HRP Bundle | sc-538356 | 200 µg Ab; 10 µg BP | $361.00 | |||
Gl Syn Antibody (F-4): m-IgGκ BP-HRP Bundle | sc-535951 | 200 µg Ab; 40 µg BP | $361.00 | |||
Gl Syn Antibody (F-4): m-IgG1 BP-HRP Bundle | sc-545658 | 200 µg Ab; 20 µg BP | $361.00 | |||
Gl Syn (F-4) Neutralizing Peptide | sc-398034 P | 100 µg/0.5 ml | $69.00 |