GITRL Antibody (EB11): sc-53973
- GITRL Antibody (EB11) is a mouse monoclonal IgG1 κ GITRL antibody provided at 200 µg/ml
- raised against recombinant full length GITRL of human origin
- recommended for detection of GITRL of human origin by WB, IF, FCM and ELISA
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GITRL Antibody (EB11) for WB applications. These reagents are now offered in bundles with GITRL Antibody (EB11) (see ordering information below).
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SEE ALSO...
GITRL Antibody (EB11) is a mouse monoclonal IgG1 kappa light chain antibody that detects the GITRL protein of human origin by western blotting (WB), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-GITRL antibody (EB11) is available in both non-conjugated and various conjugated forms, including phycoerythrin (PE) and fluorescein isothiocyanate (FITC). GITRL, or glucocorticoid-induced TNF-related ligand, is a polypeptide encoded by a cDNA derived from human umbilical endothelial cells and belongs to the tumor necrosis factor superfamily, which is crucial for regulating a wide array of biological functions such as cell proliferation, differentiation, and survival. GITRL exhibits a type 2 transmembrane topology, a characteristic feature of the TNF family, and is predominantly located on vascular endothelial cells as well as in several peripheral tissues, including the small intestine, ovary, testis, and kidney. This localization suggests GITRL may play a vital role in modulating T lymphocyte survival within these tissues. The interaction between GITRL and GITR is essential for regulating NFκB activation, and this ligand-receptor pair protects cells from activation-induced cell death (AICD), thereby contributing to immune homeostasis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GITRL Antibody (EB11) References:
- Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. | Gurney, AL., et al. 1999. Curr Biol. 9: 215-8. PMID: 10074428
- Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas. | Gruss, HJ. and Dower, SK. 1995. Blood. 85: 3378-404. PMID: 7780126
- The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. | Smith, CA., et al. 1994. Cell. 76: 959-62. PMID: 8137429
- A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. | Nocentini, G., et al. 1997. Proc Natl Acad Sci U S A. 94: 6216-21. PMID: 9177197
- Death receptors: signaling and modulation. | Ashkenazi, A. and Dixit, VM. 1998. Science. 281: 1305-8. PMID: 9721089
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GITRL Antibody (EB11) | sc-53973 | 200 µg/ml | $322.00 | |||
GITRL Antibody (EB11): m-IgG Fc BP-HRP Bundle | sc-537025 | 200 µg Ab; 10 µg BP | $361.00 | |||
GITRL Antibody (EB11): m-IgGκ BP-HRP Bundle | sc-534207 | 200 µg Ab; 40 µg BP | $361.00 | |||
GITRL Antibody (EB11): m-IgG1 BP-HRP Bundle | sc-544965 | 200 µg Ab; 20 µg BP | $361.00 | |||
GITRL Antibody (EB11) FITC | sc-53973 FITC | 200 µg/ml | $336.00 | |||
GITRL Antibody (EB11) PE | sc-53973 PE | 200 µg/ml | $349.00 |