GIT2 Antibody (E-5): sc-515310

GIT2 Antibody (E-5) is a mouse monoclonal IgM antibody that detects GIT2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GIT2 antibody (E-5) is available in a non-conjugated form, providing flexibility for various experimental needs. GIT2, a member of the GTPase-activating protein family, plays a crucial role in regulating the activity of small GTP-binding proteins, particularly those in the ADP ribosylation factor family, which are essential for vesicular trafficking within cells. Proper functioning of GIT2 is vital for maintaining cellular homeostasis and facilitating signal transduction pathways, particularly those mediated by G protein-coupled receptors. Dysregulation of GIT2 can lead to impaired receptor internalization and resensitization, which may contribute to various pathophysiological conditions, including cardiovascular diseases and metabolic disorders. GIT2 (E-5) antibody enables researchers to gain valuable insights into the mechanisms of G protein signaling and the intricate processes of cellular communication.

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GIT2 Antibody (E-5) References:

1. The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing.  |  Premont, RT., et al. 2000. J Biol Chem. 275: 22373-80. PMID: 10896954
2. Turning off the signal: desensitization of beta-adrenergic receptor function.  |  Hausdorff, WP., et al. 1990. FASEB J. 4: 2881-9. PMID: 2165947
3. An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.  |  Pei, G., et al. 1994. Proc Natl Acad Sci U S A. 91: 3633-6. PMID: 8170959
4. G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization.  |  Lefkowitz, RJ. 1998. J Biol Chem. 273: 18677-80. PMID: 9668034
5. G protein-coupled receptor kinases.  |  Pitcher, JA., et al. 1998. Annu Rev Biochem. 67: 653-92. PMID: 9759500
6. beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.  |  Premont, RT., et al. 1998. Proc Natl Acad Sci U S A. 95: 14082-7. PMID: 9826657

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GIT2 Antibody (E-5) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GIT2 Antibody (E-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GIT2 Antibody (E-5) Specifications

Alternate Product Name: GIT2

Product Clone Name: E-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 14-33

Epitope Target: GIT2

Epitope Species: human

Product Reactivity/Detection: GIT2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GIT2 Antibody (E-5): P: Blocking Peptide

The preferred GIT1/2 antibody is GIT1/2 Antibody (13): sc-135925.