GIPC Antibody (C-9): sc-166148

GIPC Antibody (C-9) is a mouse monoclonal IgG2a antibody that detects GIPC in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GIPC antibody (C-9) is raised against amino acids 1-55 of GIPC of human origin. GIPC, also known as GAIP interacting protein at the C terminus, SEMCAP-1, or synectin, plays a crucial role in cellular signaling by interacting with RGS-GAIP, a GTPase-activating protein for G(i) subunits, thereby influencing G protein-coupled receptor pathways. GIPC is primarily localized to clusters of vesicles near the plasma membrane, which is significant for involvement in regulating clathrin-coated vesicular trafficking, a process essential for the transport of proteins and lipids within cells. Additionally, GIPC has been shown to associate with membrane-bound semaphorin F (M-SemF), a protein that is vital for neuronal axon growth, suggesting GIPC may also play a role in the spatial distribution of M-SemF in the brain, further highlighting importance in neuronal development and signaling. Anti-GIPC antibody (C-9) is an invaluable tool for researchers studying these complex cellular processes and their implications in health and disease.

The preferred GIPC antibody is GIPC Antibody (B-12): sc-271822.