GIPC Antibody (B-6): sc-376697

GIPC Antibody (B-6) is a mouse monoclonal IgG2b antibody that detects GIPC in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GIPC antibody (B-6) is specific for an epitope mapping between amino acids 303-331 at the C-terminus of GIPC of human origin. GIPC monoclonal antibody (B-6), also known as GAIP interacting protein at the C terminus, SEMCAP-1, or synectin, plays a crucial role in cellular signaling by interacting with RGS-GAIP, a GTPase-activating protein that regulates G(i) subunits. GIPC is primarily localized to clusters of vesicles near the plasma membrane, where GIPC is involved in the G protein-coupled signaling pathways that govern clathrin-coated vesicular trafficking. GIPC′s localization facilitates the coordination of multiprotein complexes at cell-cell junctions in epithelial cells and neurons, which is essential for maintaining cellular communication and integrity. GIPC interacts with membrane-bound semaphorin F (M-SemF), a protein critical for neuronal axon growth, thereby influencing the subcellular distribution of M-SemF in the brain. GIPC′s ability to modulate these interactions highlights GIPC′s significance in both normal cellular function and potential pathological conditions, making anti-GIPC antibody (B-6) a valuable tool for researchers studying these complex biological processes.

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GIPC Antibody (B-6) References:

1. GIPC participates in G protein signaling downstream of insulin-like growth factor 1 receptor.  |  Booth, RA., et al. 2002. J Biol Chem. 277: 6719-25. PMID: 11751850
2. CD93 interacts with the PDZ domain-containing adaptor protein GIPC: implications in the modulation of phagocytosis.  |  Bohlson, SS., et al. 2005. J Leukoc Biol. 77: 80-9. PMID: 15459234
3. TRP1 interacting PDZ-domain protein GIPC forms oligomers and is localized to intracellular vesicles in human melanocytes.  |  Kedlaya, RH., et al. 2006. Arch Biochem Biophys. 454: 160-9. PMID: 16962991
4. GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling.  |  Varsano, T., et al. 2006. Mol Cell Biol. 26: 8942-52. PMID: 17015470
5. The role of the PDZ protein GIPC in regulating NMDA receptor trafficking.  |  Yi, Z., et al. 2007. J Neurosci. 27: 11663-75. PMID: 17959809
6. Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex.  |  Shang, G., et al. 2017. Elife. 6: PMID: 28537552
7. GIPC proteins negatively modulate Plexind1 signaling during vascular development.  |  Carretero-Ortega, J., et al. 2019. Elife. 8: PMID: 31050647
8. GIPC-Regulated IGFBP-3 Promotes HSC Migration In Vitro and Portal Hypertension In Vivo Through a β1-Integrin Pathway.  |  Yaqoob, U., et al. 2020. Cell Mol Gastroenterol Hepatol. 10: 545-559. PMID: 32447051
9. Strength and duration of GIPC-dependent signaling networks as determinants in cancer.  |  Ahmed, T., et al. 2021. Neoplasia. 23: 181-188. PMID: 33360508
10. Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport.  |  Ramonett, A., et al. 2022. Mol Biol Cell. 33: ar4. PMID: 34705526

The preferred GIPC antibody is GIPC Antibody (B-12): sc-271822.