GIF Antibody (B-2): sc-514524

GIF Antibody (B-2) is a mouse monoclonal IgG2b antibody that detects GIF (Gastric intrinsic factor) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GIF is a 417 amino acid secreted glycoprotein produced by the parietal cells of the stomach, playing a crucial role in the absorption of vitamin B12, which is essential for red blood cell formation and proper nervous system function. Once vitamin B12 binds to GIF, absorption occurs in the terminal ileum via the receptor cubilin, highlighting GIF′s importance in preventing conditions such as pernicious anemia, an autoimmune disorder that leads to the destruction of parietal cells and subsequent malabsorption of vitamin B12. Deficiencies in GIF can also result from genetic mutations in the GIF gene, leading to hereditary intrinsic factor deficiency and associated megaloblastic anemia. Anti-GIF antibody (B-2) serves as an invaluable tool for researchers studying vitamin B12 metabolism and related disorders, providing insights into the molecular mechanisms underlying these critical biological processes.

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GIF Antibody (B-2) References:

1. CD4 cell-secreted, posttranslationally modified cytokine GIF suppresses Th2 responses by inhibiting the initiation of IL-4 production.  |  Kim-Saijo, M., et al. 2008. Proc Natl Acad Sci U S A. 105: 19402-7. PMID: 19036925
2. GIF-0173 protects against cerebral infarction through DP1 receptor activation.  |  Thura, M., et al. 2009. Exp Neurol. 219: 481-91. PMID: 19576888
3. S100A9, GIF and AAT as potential combinatorial biomarkers in gastric cancer diagnosis and prognosis.  |  Wu, W., et al. 2012. Proteomics Clin Appl. 6: 152-62. PMID: 22532451
4. Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant.  |  Chery, C., et al. 2013. Biochimie. 95: 995-1001. PMID: 23402911
5. Gadolinium-Induced Fibrosis.  |  Todd, DJ. and Kay, J. 2016. Annu Rev Med. 67: 273-91. PMID: 26768242
6. Gastrointestinal Failure in Critically Ill Patients With Cirrhosis.  |  Alukal, JJ. and Thuluvath, PJ. 2019. Am J Gastroenterol. 114: 1231-1237. PMID: 31185004
7. Antiferroptotic Activities of Oxindole GIF-0726-r Derivatives: Involvement of Ferrous Iron Coordination and Free-Radical Scavenging Capacities.  |  Takahashi, M., et al. 2023. ACS Chem Neurosci. 14: 1826-1833. PMID: 37104649
8. Antibody-mediated neutralization of galectin-3 as a strategy for the treatment of systemic sclerosis.  |  Ortega-Ferreira, C., et al. 2023. Nat Commun. 14: 5291. PMID: 37652913
9. Local resection for solid pseudopapillary neoplasms of the pancreas shows improved postoperative gastrointestinal function and reduced mental stress: a multiquestionnaire survey from a large cohort.  |  Hua, Y., et al. 2023. Int J Surg. 109: 3815-3826. PMID: 37830944
10. Melanosomal localization is required for GIF-2115/2250 to inhibit melanogenesis in B16F10 melanoma cells.  |  Sakurai, A., et al. 2024. Int J Cosmet Sci. 46: 668-679. PMID: 38327040

The preferred GIF antibody is GIF Antibody (D-6): sc-514523.