GHR Antibody (MAB 7): sc-69882

GHR Antibody (MAB 7) is a mouse monoclonal IgG1 antibody that detects growth hormone receptor (GHR) in rabbit, porcine, equine, feline, and canine samples through functional assays. GHR plays a crucial role in mediating the effects of growth hormone (GH), which is essential for regulating body growth and various metabolic processes. Located as an integral membrane protein, GHR is a member of the cytokine receptor family, characterized by the presence of soluble forms. The soluble form of GHR, known as GH-binding protein (GHBP), is produced through proteolytic cleavage of GHR′s extracellular domain. GHBP′s significance lies in its association with growth hormone insensitivity syndrome (GHIS), where reduced levels can lead to impaired growth and metabolic dysfunction. GHR is transcribed from at least two distinct promoters, resulting in two isoforms, GHR 1A and GHR 1B, both expressed in the liver, while GHR 1B is additionally found in muscle, uterus, and ovary tissues. Anti-GHR antibody (MAB 7) effectively detects this important receptor, making GHR (MAB 7) monoclonal antibody a valuable tool for researchers studying growth hormone signaling pathways and related disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GHR Antibody (MAB 7) References:

1. The exon-3 deletion of the growth hormone receptor (GHR) gene still has a limited impact in clinical endocrinology.  |  Bougnères, P. 2010. J Clin Endocrinol Metab. 95: 56-9. PMID: 20056809
2. Heterozygous GHR gene mutation in a child with idiopathic short stature.  |  Pagani, S., et al. 2014. J Pediatr Endocrinol Metab. 27: 329-34. PMID: 24150201
3. Acute heat stress and dietary methionine effects on IGF-I, GHR, and UCP mRNA expression in liver and muscle of quails.  |  Del Vesco, AP., et al. 2014. Genet Mol Res. 13: 7294-303. PMID: 24615098
4. Development and characterization of a novel GHR antibody antagonist, GF185.  |  Sun, F., et al. 2015. Int J Biol Macromol. 79: 864-70. PMID: 26051340
5. Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer.  |  Wang, R., et al. 2020. Mol Genet Genomic Med. 8: e1474. PMID: 32869542
6. Enhanced Bioactivity of a Human GHR Antagonist Generated by Solid-Phase Site-Specific PEGylation.  |  Wang, Y., et al. 2021. Biomacromolecules. 22: 299-308. PMID: 33295758
7. Growth Hormone Receptor (Ghr) 6ω Pseudoexon Activation: A Novel Cause Of Severe Growth Hormone Insensitivity (Ghi).  |  Cottrell, E., et al. 2021. J Clin Endocrinol Metab. 107: e401-16. PMID: 34318893
8. Mutations Affecting Mammalian Aging: GH and GHR vs IGF-1 and Insulin.  |  Bartke, A. and Brown-Borg, H. 2021. Front Genet. 12: 667355. PMID: 34899820
9. A novel GHR variant in the first patient of Indian origin with genetically proven growth hormone insensitivity.  |  Nikith, ZS., et al. 2022. Indian J Endocrinol Metab. 26: 190-191. PMID: 35873929
10. Associations of GHR, IGF-1 and IGFBP-3 expression in adipose tissue cells with obesity-related alterations in corresponding circulating levels and adipose tissue function in children.  |  Kempf, E., et al. 2022. Adipocyte. 11: 630-642. PMID: 36384443

The preferred GHR antibody is GHR Antibody (B-10): sc-137185.