GHR Antibody (MAB 5): sc-69880

GHR Antibody (MAB 5) is a mouse monoclonal IgG2b antibody that detects growth hormone receptor (GHR) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). GHR is a crucial integral membrane protein that plays a significant role in mediating the effects of growth hormone, which is essential for regulating body growth and various metabolic processes. The importance of GHR extends beyond its primary function, as GHR is also a member of the cytokine receptor family, which is characterized by the presence of soluble forms of the protein. One such soluble form is the growth hormone-binding protein (GHBP), produced through the proteolytic cleavage of GHR′s extracellular domain. Notably, reduced levels of GHBP have been linked to growth hormone insensitivity syndrome, highlighting the clinical relevance of GHR in endocrine disorders. GHR is transcribed from at least two distinct promoters, resulting in two isoforms, GHR 1A and GHR 1B, both of which are expressed in the liver, while GHR 1B is additionally found in muscle, uterus, and ovarian tissues. The diverse expression patterns and functional implications of GHR underscore GHR′s significance in both normal physiology and disease states, making anti-GHR antibody (MAB 5) an invaluable tool for researchers studying growth hormone signaling pathways and related metabolic conditions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GHR Antibody (MAB 5) References:

1. Physiology and disorders of the growth hormone receptor (GHR) and GH-GHR signal transduction.  |  Rosenbloom, AL. 2000. Endocrine. 12: 107-19. PMID: 10905371
2. Endocrine parameters and phenotypes of the growth hormone receptor gene disrupted (GHR-/-) mouse.  |  List, EO., et al. 2011. Endocr Rev. 32: 356-86. PMID: 21123740
3. GHR/PRLR Heteromultimer Is Composed of GHR Homodimers and PRLR Homodimers.  |  Liu, Y., et al. 2016. Mol Endocrinol. 30: 504-17. PMID: 27003442
4. TIMP3 Modulates GHR Abundance and GH Sensitivity.  |  Zhang, Y., et al. 2016. Mol Endocrinol. 30: 587-99. PMID: 27075707
5. A case report and literature review of monoallelic mutation of GHR.  |  Mitani, M., et al. 2019. J Pediatr Endocrinol Metab. 32: 415-419. PMID: 30893054
6. GHR knockdown enhances the sensitivity of HCC cells to sorafenib.  |  Gao, S., et al. 2020. Aging (Albany NY). 12: 18127-18136. PMID: 32970612
7. GHR is involved in gastric cell growth and apoptosis via PI3K/AKT signalling.  |  Yan, HZ., et al. 2021. J Cell Mol Med. 25: 2450-2458. PMID: 33492754
8. A Balanced Act: The Effects of GH-GHR-IGF1 Axis on Mitochondrial Function.  |  Hu, B., et al. 2021. Front Cell Dev Biol. 9: 630248. PMID: 33816476
9. The inhibition of GHR enhanced cytotoxic effects of etoposide on neuroblastoma.  |  Zhang, H., et al. 2021. Cell Signal. 86: 110081. PMID: 34252534
10. The nuclear-localized GHR is involved in the cell proliferation of gastric cancer, and pegvisomant may be an important potential drug to inhibit the proliferation of gastric cancer cells.  |  Meng, Y., et al. 2022. Biochem Cell Biol. 100: 125-135. PMID: 35061546

The preferred GHR antibody is GHR Antibody (B-10): sc-137185.