GHR Antibody (MAB 263): sc-57161
- GHR Antibody (MAB 263) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 200 µg/ml
- raised against purified GHR of rat and rabbit origin
- recommended for detection of GHR of mouse, rat, human and rabbit origin by WB, IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for partial blocking of binding of GH in rabbit and rat, and has been used as a growth hormone agonist, sc-57161 L, 200 µg/0.1 ml
- See GHR (B-10): sc-137185 for GHR antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for GHR Antibody (MAB 263) for WB and IHC(P) applications. These reagents are now offered in bundles with GHR Antibody (MAB 263) (see ordering information below).
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GHR Antibody (MAB 263) is a mouse monoclonal IgG1 antibody that detects growth hormone receptor (GHR) in mouse, rat, human, and rabbit samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). GHR is a crucial integral membrane protein that plays a significant role in mediating the effects of growth hormone (GH), which is essential for regulating body growth and various metabolic processes. GHR (MAB 263) antibody belongs to the cytokine receptor family, known for existing in both membrane-bound and soluble forms. The soluble form, known as GH-binding protein (GHBP), is produced through proteolytic cleavage of GHR′s extracellular domain and serves to modulate GH activity in the bloodstream. Notably, reduced GHBP levels are linked to growth hormone insensitivity syndrome, highlighting GHR′s clinical relevance in growth regulation. GHR is transcribed from at least two distinct promoters, resulting in two isoforms, GHR 1A and GHR 1B, with GHR 1A and 1B being expressed in the liver, while GHR 1B is additionally found in muscle, uterus, and ovary tissues, underscoring diverse physiological roles. Anti-GHR antibody (MAB 263) is an invaluable tool for researchers investigating the complexities of growth hormone signaling and implications in health and disease.
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GHR Antibody (MAB 263) References:
- Deconstructing the Growth Hormone Receptor(GHR): Physical and Metabolic Phenotypes of Tissue-Specific GHR Gene-Disrupted Mice. | Young, JA., et al. 2016. Prog Mol Biol Transl Sci. 138: 27-39. PMID: 26940385
- GH and GHR signaling in human disease. | Guevara-Aguirre, J., et al. 2018. Growth Horm IGF Res. 38: 34-38. PMID: 29395968
- Post-Receptor Inhibitors of the GHR-JAK2-STAT Pathway in the Growth Hormone Signal Transduction. | Wójcik, M., et al. 2018. Int J Mol Sci. 19: PMID: 29932147
- Genetic causes of growth hormone insensitivity beyond GHR. | Hwa, V., et al. 2021. Rev Endocr Metab Disord. 22: 43-58. PMID: 33029712
- Hypothalamic GHR-SIRT1 Axis in Fasting. | de Lima, JBM., et al. 2021. Cells. 10: PMID: 33919674
- ARCGHR Neurons Regulate Muscle Glucose Uptake. | de Lima, JBM., et al. 2021. Cells. 10: PMID: 34063647
- Mutations in GHR and IGF1R Genes as a Potential Reason for the Lack of Catch-Up Growth in SGA Children. | Stróżewska, W., et al. 2022. Genes (Basel). 13: PMID: 35627241
- GHR expression and prostate cancer proliferation. | Thomas, T. 2023. Nat Rev Urol. 20: 131. PMID: 36781984
- Direct and systemic actions of growth hormone receptor (GHR)-signaling on hepatic glycolysis, de novo lipogenesis and insulin sensitivity, associated with steatosis. | Vázquez-Borrego, MC., et al. 2023. Metabolism. 144: 155589. PMID: 37182789
- Local GHR roles in regulation of mitochondrial function through mitochondrial biogenesis during myoblast differentiation. | Hu, B., et al. 2023. Cell Commun Signal. 21: 148. PMID: 37337300
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GHR Antibody (MAB 263) | sc-57161 | 200 µg/ml | $322.00 | |||
GHR Antibody (MAB 263): m-IgG Fc BP-HRP Bundle | sc-539049 | 200 µg Ab; 10 µg BP | $361.00 | |||
GHR Antibody (MAB 263): m-IgG1 BP-HRP Bundle | sc-541228 | 200 µg Ab; 20 µg BP | $361.00 | |||
GHR Antibody (MAB 263) FITC | sc-57161 FITC | 200 µg/ml | $336.00 | |||
GHR Antibody (MAB 263) L | sc-57161 L | 200 µg/0.1 ml | $322.00 | |||
GHR Antibody (MAB 263) PE | sc-57161 PE | 200 µg/ml | $349.00 |