GHR Antibody (3H2186): sc-71146

GHR Antibody (3H2186) is a mouse monoclonal IgG1 antibody that detects growth hormone receptor (GHR) in mouse, rat, human, and rabbit samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). GHR is a crucial integral membrane protein that plays a significant role in mediating the effects of growth hormone, which is essential for regulating body growth and metabolic processes. The importance of GHR extends beyond its primary function, as GHR is also involved in the generation of a soluble form known as growth hormone-binding protein (GHBP), produced through the proteolytic cleavage of its extracellular domain. This soluble form is vital for modulating the availability of growth hormone in circulation, and reduced levels of GHBP have been linked to growth hormone insensitivity syndrome, highlighting the clinical relevance of GHR in growth regulation and metabolic health. GHR is transcribed from at least two distinct promoters, resulting in two isoforms, GHR 1A and GHR 1B, with GHR 1A and 1B being expressed in the liver, while GHR 1B is additionally found in muscle, uterus, and ovary tissues, indicating its diverse roles in different biological contexts. Anti-GHR antibody (3H2186) is an invaluable tool for researchers studying the intricate mechanisms of growth hormone signaling and its implications in various physiological and pathological conditions.

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GHR Antibody (3H2186) References:

1. Reduced growth hormone receptor (GHR) messenger ribonucleic acid in liver of periparturient cattle is caused by a specific down-regulation of GHR 1A that is associated with decreased insulin-like growth factor I.  |  Kobayashi, Y., et al. 1999. Endocrinology. 140: 3947-54. PMID: 10465263
2. Lipopolysaccharide (LPS) directly suppresses growth hormone receptor (GHR) expression through MyD88-dependent and -independent Toll-like receptor-4/MD2 complex signaling pathways.  |  Dejkhamron, P., et al. 2007. Mol Cell Endocrinol. 274: 35-42. PMID: 17601656
3. Two-year body composition analyses of long-lived GHR null mice.  |  Berryman, DE., et al. 2010. J Gerontol A Biol Sci Med Sci. 65: 31-40. PMID: 19901018
4. Growth hormone receptor (GHR) RNAi decreases proliferation and enhances apoptosis in CMT-U27 canine mammary carcinoma cell line.  |  Pawłowski, KM., et al. 2012. Vet Comp Oncol. 10: 2-15. PMID: 22235976
5. Association of a single-nucleotide polymorphism (rs6180) in GHR gene with plural tissue weight.  |  Fujihara, J., et al. 2016. J Genet. 95: 189-92. PMID: 27019449
6. Differential effects of early-life nutrient restriction in long-lived GHR-KO and normal mice.  |  Fang, Y., et al. 2017. Geroscience. 39: 347-356. PMID: 28523599
7. The GHR-R antagonist JMV 2959 neither induces malaise nor alters the malaise property of LiCl in the adult male rat.  |  Rodriguez, JA., et al. 2018. Physiol Behav. 183: 46-48. PMID: 29056353
8. Overexpression of ghr-miR166b generates resistance against Bemisia tabaci infestation in Gossypium hirsutum plants.  |  Wamiq, G. and Khan, JA. 2018. Planta. 247: 1175-1189. PMID: 29397416
9. Endocytosis and Degradation of Pegvisomant and a Potential New Mechanism That Inhibits the Nuclear Translocation of GHR.  |  Lan, H., et al. 2019. J Clin Endocrinol Metab. 104: 1887-1899. PMID: 30602026
10. Gender Specificity and Local Socioeconomic Influence on Association of GHR fl/d3 Polymorphism With Growth and Metabolism in Children and Adolescents.  |  Chen, X., et al. 2022. Front Pediatr. 10: 546080. PMID: 35402349

The preferred GHR antibody is GHR Antibody (B-10): sc-137185.