GGTase-IIβ Antibody (B-12): sc-365901
- GGTase-IIβ Antibody (B-12) is a mouse monoclonal IgG2b κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 139-331 mapping at the C-terminus of GGTase-IIβ of human origin
- recommended for detection of GGTase-IIβ of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GGTase-IIβ Antibody (B-12) for WB and IHC(P) applications. These reagents are now offered in bundles with GGTase-IIβ Antibody (B-12) (see ordering information below).
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GGTase-IIβ Antibody (B-12) is a mouse monoclonal IgG2b antibody that detects GGTase-IIβ in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). GGTase-IIβ plays a crucial role in the post-translational modification of Rab GTPases, which are essential for intracellular vesicle trafficking and membrane dynamics. The proper functioning of Rab proteins is vital for numerous cellular processes, including endocytosis, exocytosis, and organelle biogenesis, making GGTase-IIβ a key player in maintaining cellular homeostasis. The interaction of GGTase-IIβ with Rab GTPases is particularly important as GGTase-IIβ facilitates the geranylgeranylation of these proteins, allowing them to anchor to cellular membranes and participate in signaling pathways. Anti-GGTase-IIβ antibody (B-12) enables researchers to gain insights into the regulatory mechanisms of vesicular transport and the implications of Rab GTPase dysfunction in various diseases, including cancer and neurodegenerative disorders.
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GGTase-IIβ Antibody (B-12) References:
- The cytoplasmic domain of chondrolectin interacts with the beta-subunit of Rab geranylgeranyl transferase. | Claessens, A., et al. 2008. Cell Mol Biol Lett. 13: 250-9. PMID: 18161010
- GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase. | Kuchay, S., et al. 2019. Nat Struct Mol Biol. 26: 628-636. PMID: 31209342
- Expression of Rab Prenylation Pathway Genes and Relation to Disease Progression in Choroideremia. | Fry, LE., et al. 2021. Transl Vis Sci Technol. 10: 12. PMID: 34254989
- Protective effects of intrathecal injection of AAV9-RabGGTB-GFP+ in SOD1G93A mice. | Gao, T., et al. 2023. Front Aging Neurosci. 15: 1092607. PMID: 36967828
- Prenyltransferase gene expression reveals an essential role of prenylation for the inflammatory response in human gingival fibroblasts. | Diehl, D., et al. 2023. J Periodontol. 94: 1450-1460. PMID: 37432945
- Rab Geranylgeranyltransferase Subunit Beta as a Potential Indicator to Assess the Progression of Amyotrophic Lateral Sclerosis. | Yang, J., et al. 2023. Brain Sci. 13: PMID: 38002490
- RABGGTB plays a critical role in ALS pathogenesis. | Ma, H., et al. 2024. Brain Res Bull. 206: 110833. PMID: 38042502
- Sex-based Dysregulation of Inflammation-related Genes in Periodontitis. | Ghafouri-Fard, S., et al. 2023. Int J Mol Cell Med. 12: 300-309. PMID: 38751653
- Assessment of Rab geranylgeranyltransferase subunit beta in amyotrophic lateral sclerosis. | Yang, J., et al. 2024. Front Neurol. 15: 1447461. PMID: 39224887
- Studies of the mouse Rab geranylgeranyl transferase beta subunit: gene structure, expression and regulation. | Chinpaisal, C., et al. 1997. Gene. 184: 237-43. PMID: 9031634
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GGTase-IIβ Antibody (B-12) | sc-365901 | 200 µg/ml | $316.00 | |||
GGTase-IIβ Antibody (B-12): m-IgGκ BP-HRP Bundle | sc-535271 | 200 µg Ab; 40 µg BP | $354.00 | |||
GGTase-IIβ Antibody (B-12): m-IgG2b BP-HRP Bundle | sc-549380 | 200 µg Ab; 10 µg BP | $354.00 |