GGTase-Iβ Antibody (B-11): sc-515131

GGTase-Iβ Antibody (B-11) is a mouse monoclonal IgG1 antibody that detects GGTase-Iβ in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GGTase-Iβ plays a crucial role in the post-translational modification of proteins, specifically through the process of geranylgeranylation, which is essential for the proper functioning of various signaling pathways, including the TGF-β1 signaling pathway. This modification involves the attachment of a 20-carbon geranylgeranyl group to the C-terminal cysteine residues of target proteins, which is vital for their membrane localization and activity. The presence of the CAAX motif, where "A" represents an aliphatic amino acid and "X" is leucine, is a key determinant for the substrate specificity of GGTase-Iβ. By facilitating the geranylgeranylation of proteins, GGTase-Iβ ensures the activation of downstream signaling cascades that regulate critical cellular processes such as growth, differentiation, and apoptosis. GGTase-Iβ (B-11) antibody is an invaluable tool for researchers studying these pathways and the intricate roles of geranylgeranylated proteins in human health and disease.

The preferred GGTase-Iβ antibody is GGTase-Iβ Antibody (D-11): sc-376854.