GGPS1 Antibody (E-1): sc-271680
- GGPS1 Antibody (E-1) is a mouse monoclonal IgG2b κ GGPS1 antibody, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 1-300 representing full length GGPS1 of human origin
- GGPS1 Antibody (E-1) is recommended for detection of GGPS1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-GGPS1 Antibody (E-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GGPS1 Antibody (E-1) for WB applications. These reagents are now offered in bundles with GGPS1 Antibody (E-1) (see ordering information below).
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SEE ALSO...
GGPS1 Antibody (E-1) is a mouse monoclonal IgG2b kappa light chain antibody that detects GGPS1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GGPS1 (E-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GGPS1, also known as geranylgeranyl diphosphate synthase 1, GGPPS, or GGPPSase, is a crucial enzyme in the FPP/GGPP synthetase family of trans-prenyltransferases, primarily expressed in the testis, heart, and skeletal muscle. GGPS1 is localized in the cytoplasm, where GGPS1 catalyzes the synthesis of geranylgeranyl pyrophosphate (GGPP), a vital precursor for the post-translational modification of proteins through geranylgeranylation, which is essential for proper functioning of various signaling pathways. GGPP formation is particularly important as GGPP regulates the activity of the nuclear hormone receptor LXRα, influencing lipid metabolism and cellular homeostasis. GGPS1 functions as an oligomeric molecule, facilitating the condensation of farnesyl diphosphate with isopentenyl diphosphate to produce GGPP. GGPS1 contains five conserved amino acid motifs characteristic of trans-prenyltransferases and features three potential N-glycosylation sites, which may play a role in enzymatic activity and stability.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GGPS1 Antibody (E-1) References:
- Human geranylgeranyl diphosphate synthase. cDNA cloning and expression. | Kuzuguchi, T., et al. 1999. J Biol Chem. 274: 5888-94. PMID: 10026212
- Identification of the GGPS1 genes encoding geranylgeranyl diphosphate synthases from mouse and human. | Kainou, T., et al. 1999. Biochim Biophys Acta. 1437: 333-40. PMID: 10101267
- The branch point enzyme of the mevalonate pathway for protein prenylation is overexpressed in the ob/ob mouse and induced by adipogenesis. | Vicent, D., et al. 2000. Mol Cell Biol. 20: 2158-66. PMID: 10688662
- Five geranylgeranyl diphosphate synthases expressed in different organs are localized into three subcellular compartments in Arabidopsis. | Okada, K., et al. 2000. Plant Physiol. 122: 1045-56. PMID: 10759500
- Geranylgeranyl-pyrophosphate (GGPP) synthase is down-regulated during differentiation of osteoblastic cell line MC3T3-E1. | Yoshida, T., et al. 2006. FEBS Lett. 580: 5203-7. PMID: 16978613
- Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. | Guo, RT., et al. 2007. Proc Natl Acad Sci U S A. 104: 10022-7. PMID: 17535895
- Human geranylgeranyl diphosphate synthase: isolation of the cDNA, chromosomal mapping and tissue expression. | Ericsson, J., et al. 1998. J Lipid Res. 39: 1731-9. PMID: 9741684
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GGPS1 Antibody (E-1) | sc-271680 | 200 µg/ml | $316.00 | |||
GGPS1 Antibody (E-1): m-IgGκ BP-HRP Bundle | sc-522022 | 200 µg Ab, 40 µg BP | $354.00 | |||
GGPS1 Antibody (E-1): m-IgG2b BP-HRP Bundle | sc-548992 | 200 µg Ab; 10 µg BP | $354.00 | |||
GGPS1 Antibody (E-1) AC | sc-271680 AC | 500 µg/ml, 25% agarose | $416.00 | |||
GGPS1 Antibody (E-1) HRP | sc-271680 HRP | 200 µg/ml | $316.00 | |||
GGPS1 Antibody (E-1) FITC | sc-271680 FITC | 200 µg/ml | $330.00 | |||
GGPS1 Antibody (E-1) PE | sc-271680 PE | 200 µg/ml | $343.00 | |||
GGPS1 Antibody (E-1) Alexa Fluor® 488 | sc-271680 AF488 | 200 µg/ml | $357.00 | |||
GGPS1 Antibody (E-1) Alexa Fluor® 546 | sc-271680 AF546 | 200 µg/ml | $357.00 | |||
GGPS1 Antibody (E-1) Alexa Fluor® 594 | sc-271680 AF594 | 200 µg/ml | $357.00 | |||
GGPS1 Antibody (E-1) Alexa Fluor® 647 | sc-271680 AF647 | 200 µg/ml | $357.00 | |||
GGPS1 Antibody (E-1) Alexa Fluor® 680 | sc-271680 AF680 | 200 µg/ml | $357.00 | |||
GGPS1 Antibody (E-1) Alexa Fluor® 790 | sc-271680 AF790 | 200 µg/ml | $357.00 |