Gemin4 Antibody (F-2): sc-166418

Gemin4 Antibody (F-2) is a mouse monoclonal IgG2a light chain antibody that detects Gemin4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gemin4 is a crucial component of the SMN core complex, which is vital for the assembly of small nuclear ribonucleoproteins (snRNPs) in the cytoplasm, facilitating their biogenesis, delivery, and recycling to the spliceosome. This process is essential for pre-mRNA splicing, a key step in gene expression regulation. In the nucleus, Gemin4 is predominantly localized near coiled bodies within subnuclear structures known as gems, which are rich in splicing factors and snRNPs, as well as in the nucleolus. The proper functioning of Gemin4 is critical, as mutations or deletions in the SMN complex, which includes Gemin4, are linked to spinal muscular atrophy (SMA), a severe neurodegenerative disease. The human Gemin4 gene is located on chromosome 17p13.3, highlighting its significance in genetic studies and potential therapeutic targets for SMA. Anti-Gemin4 antibody (F-2) provides a reliable tool for researchers investigating the role of this protein in cellular processes and disease mechanisms.

The preferred Gemin4 antibody is Gemin4 Antibody (E-8): sc-365424.