Gemin4 Antibody (17D10): sc-136199

Gemin4 Antibody (17D10) is a mouse monoclonal IgG1 antibody that detects Gemin4 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Gemin4 is a crucial component of the SMN core complex, playing a vital role in the assembly of small nuclear ribonucleoproteins (snRNPs) in the cytoplasm, which is essential for the biogenesis, delivery, and recycling of snRNPs to the spliceosome. In the nucleus, Gemin4 is predominantly localized near coiled bodies within subnuclear structures known as gems, which are rich in splicing factors and snRNPs, and also in the nucleolus. The proper functioning of Gemin4 is critical, as mutations or deletions in the SMN complex, which includes Gemin4, are linked to spinal muscular atrophy (SMA), a severe neurodegenerative disease. The human Gemin4 gene is located on chromosome 17p13.3, highlighting its significance in genetic studies and potential therapeutic targets for SMA. Anti-Gemin4 antibody (17D10) is an invaluable tool for researchers investigating the molecular mechanisms underlying RNA processing and related pathologies.

The preferred Gemin4 antibody is Gemin4 Antibody (E-8): sc-365424.