Gemin2 Antibody (E-6): sc-166160

Gemin2 Antibody (E-6) is a mouse monoclonal IgG1 antibody that detects Gemin2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gemin2 plays a crucial role in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), which are essential for pre-mRNA splicing, a fundamental process in gene expression regulation. The interaction of Gemin2 with the survival of motor neuron (SMN) complex is vital for proper functioning of the spliceosome, and disruptions in this interaction can lead to severe consequences, such as the neurodegenerative disease spinal muscular atrophy (SMA). Gemin2 is predominantly located in both the cytoplasm and nucleus, where Gemin2 is concentrated in subnuclear structures known as gems, which are critical for storage and assembly of snRNPs. Gemin2 presence in the spinal cord highlights importance in motor neuron health, and Gemin2 expression can be induced by transforming growth factor beta (TGFβ), indicating potential role in cellular responses to stress or injury. Additionally, Gemin2 is expressed at elevated levels in certain E-cadherin negative human carcinoma cell lines, suggesting possible involvement in cancer biology. With diverse applications and significant biological relevance, anti-Gemin2 antibody (E-6) is an invaluable tool for researchers studying splicing mechanisms and related diseases.

The preferred Gemin2 antibody is Gemin2 Antibody (1G9): sc-33703.