Gelsolin Antibody (H-5): sc-398244
- Gelsolin Antibody (H-5) is a mouse monoclonal IgG1 κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 759-782 at the C-terminus of Gelsolin of human origin
- recommended for detection of plasma and cytoplasmic Gelsolin of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Gelsolin Antibody (H-5) for WB applications. These reagents are now offered in bundles with Gelsolin Antibody (H-5) (see ordering information below).
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Gelsolin Antibody (H-5) is a mouse monoclonal IgG1 antibody that detects Gelsolin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gelsolin plays a crucial role in regulating actin filament dynamics, which is essential for various cellular processes, including motility, shape maintenance, and intracellular transport. By severing actin filaments in the presence of calcium, Gelsolin facilitates cytoskeleton remodeling, allowing cells to respond effectively to environmental cues. This dynamic regulation is particularly important in leukocytes and platelets, where actin rearrangement is vital for immune responses and clot formation. Gelsolin′s ability to exist in both secreted and intracellular forms highlights its versatility and importance in maintaining cellular homeostasis. The presence of Gelsolin in the extracellular space serves as a protective mechanism, preventing toxic effects of free actin released during cell necrosis, thereby contributing to tissue integrity and repair. Anti-Gelsolin antibody (H-5) is an invaluable tool for researchers studying actin dynamics and related cellular functions, providing insights into molecular mechanisms underlying various physiological and pathological processes.
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Gelsolin Antibody (H-5) References:
- Induction of apoptosis by gelsolin truncates. | Fujita, H., et al. 1999. Ann N Y Acad Sci. 886: 217-20. PMID: 10667223
- The gelsolin family of actin regulatory proteins: modular structures, versatile functions. | McGough, AM., et al. 2003. FEBS Lett. 552: 75-81. PMID: 14527663
- Plasma gelsolin as a biomarker of inflammation. | DiNubile, MJ. 2008. Arthritis Res Ther. 10: 124. PMID: 19105851
- Gelsolin as therapeutic target in Alzheimer's disease. | Carro, E. 2010. Expert Opin Ther Targets. 14: 585-92. PMID: 20433353
- Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention. | Solomon, JP., et al. 2012. Crit Rev Biochem Mol Biol. 47: 282-96. PMID: 22360545
- Gelsolin suppresses gastric cancer metastasis through inhibition of PKR-p38 signaling. | Yuan, X., et al. 2016. Oncotarget. 7: 53459-53470. PMID: 27419625
- Severe ocular involvement in hereditary gelsolin amyloidosis. | da Silva, NFP. and Beirão, JNM. 2021. Porto Biomed J. 6: e146. PMID: 34651091
- The Molecular Chaperone CCT Sequesters Gelsolin and Protects it from Cleavage by Caspase-3. | Cuéllar, J., et al. 2022. J Mol Biol. 434: 167399. PMID: 34896365
- Plasma gelsolin levels are associated with diabetes, sex, race, and poverty. | Noren Hooten, N., et al. 2023. J Transl Med. 21: 190. PMID: 36899335
- Gelsolin knockdown confers radiosensitivity to glioblastoma cells. | Gao, D., et al. 2024. Cancer Med. 13: e7286. PMID: 38803199
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gelsolin Antibody (H-5) | sc-398244 | 200 µg/ml | $316.00 | |||
Gelsolin Antibody (H-5): m-IgG Fc BP-HRP Bundle | sc-538403 | 200 µg Ab; 10 µg BP | $354.00 | |||
Gelsolin Antibody (H-5): m-IgGκ BP-HRP Bundle | sc-536012 | 200 µg Ab; 40 µg BP | $354.00 | |||
Gelsolin Antibody (H-5): m-IgG1 BP-HRP Bundle | sc-545684 | 200 µg Ab; 20 µg BP | $354.00 | |||
Gelsolin (H-5) Neutralizing Peptide | sc-398244 P | 100 µg/0.5 ml | $68.00 |