GDNF Antibody (E-10): sc-398555
- GDNF Antibody (E-10) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 174-209 near the C-terminus of GDNF of human origin
- recommended for detection of GDNF p20 of mouse, rat and human origin by WB, IP, IF and ELISA
- See GDNF (B-8): sc-13147 for GDNF antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GDNF Antibody (E-10) for WB applications. These reagents are now offered in bundles with GDNF Antibody (E-10) (see ordering information below).
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SEE ALSO...
GDNF Antibody (E-10) is a mouse monoclonal IgG2a light chain antibody that detects glial cell line-derived neurotrophic factor (GDNF) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GDNF plays a crucial role in the survival and maintenance of midbrain dopaminergic neurons, which are essential for motor control and are significantly affected in neurodegenerative diseases like Parkinson′s disease. GDNF is primarily secreted and acts on neurons through GFRα1 receptor, initiating signaling pathways that promote neuronal survival and differentiation. GDNF′s structure as a glycosylated, disulfide-bonded homodimer, featuring seven conserved cysteine residues, is vital for stability and biological activity, allowing effective binding to receptors and activation of downstream signaling cascades. Given neuroprotective properties, anti-GDNF antibody (E-10) has garnered interest for therapeutic applications in neurodegenerative disorders, highlighting the importance of research aimed at understanding and potentially treating such conditions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GDNF Antibody (E-10) | sc-398555 | 200 µg/ml | $322.00 | |||
GDNF Antibody (E-10): m-IgG Fc BP-HRP Bundle | sc-538470 | 200 µg Ab; 10 µg BP | $361.00 | |||
GDNF Antibody (E-10): m-IgGκ BP-HRP Bundle | sc-536092 | 200 µg Ab; 40 µg BP | $361.00 | |||
GDNF Antibody (E-10): m-IgG2a BP-HRP Bundle | sc-548314 | 200 µg Ab; 10 µg BP | $361.00 | |||
GDNF (E-10) Neutralizing Peptide | sc-398555 P | 100 µg/0.5 ml | $69.00 |