GDF-9 Antibody (C-6): sc-514933

GDF-9 Antibody (C-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects GDF-9 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GDF-9 (C-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GDF-9, a member of the growth/differentiation factor family within the transforming growth factor-beta (TGF-β) superfamily, plays a crucial role in ovarian folliculogenesis, which is essential for female fertility. GDF-9 is primarily expressed in the ovary, where GDF-9 regulates the growth and differentiation of ovarian follicles, thereby influencing reproductive processes. GDF-9 interacts with other growth factors, such as GDF-8 (also known as myostatin), which is a negative regulator of muscle growth, highlighting the intricate network of signaling pathways that govern developmental and physiological processes. Absence or dysfunction of GDF-9 can lead to reproductive disorders, underscoring GDF-9′s importance in maintaining ovarian function and overall fertility.

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GDF-9 Antibody (C-6) References:

1. Recombinant growth differentiation factor-9 (GDF-9) enhances growth and differentiation of cultured early ovarian follicles.  |  Hayashi, M., et al. 1999. Endocrinology. 140: 1236-44. PMID: 10067849
2. Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis.  |  Aaltonen, J., et al. 1999. J Clin Endocrinol Metab. 84: 2744-50. PMID: 10443672
3. Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.  |  Lee, SJ. 1991. Proc Natl Acad Sci U S A. 88: 4250-4. PMID: 2034669
4. Expression of GDF-9, BMP-15 and their receptors in mammalian ovary follicles.  |  Sun, RZ., et al. 2010. J Mol Histol. 41: 325-32. PMID: 20857181
5. The transforming growth factor-beta family.  |  Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
6. Expression of CDC6 and GDF-9 and their clinicopathological significances in benign and malignant lesions of the gallbladder.  |  Shu, GS., et al. 2012. Cancer Biomark. 11: 107-14. PMID: 23011157
7. Association of plasma GDF-9 or GDF-15 levels with bone parameters in polycystic ovary syndrome.  |  Berberoglu, Z., et al. 2015. J Bone Miner Metab. 33: 101-8. PMID: 24430093
8. GDF-9 and BMP-15 direct the follicle symphony.  |  Sanfins, A., et al. 2018. J Assist Reprod Genet. 35: 1741-1750. PMID: 30039232
9. Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily.  |  Storm, EE., et al. 1994. Nature. 368: 639-43. PMID: 8145850
10. GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines.  |  McPherron, AC. and Lee, SJ. 1993. J Biol Chem. 268: 3444-9. PMID: 8429021
11. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.  |  McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826
12. Growth/differentiation factor-5 induces angiogenesis in vivo.  |  Yamashita, H., et al. 1997. Exp Cell Res. 235: 218-26. PMID: 9281371

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GDF-9 Antibody (C-6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-GDF-9 Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GDF-9 Antibody (C-6) Specifications

Alternate Product Name: GDF-9

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 331-454

Epitope Target: GDF-9

Epitope Species: human

Product Reactivity/Detection: GDF-9

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for GDF-9 Antibody (C-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin