G_β Antibody (F-8): sc-136975

Gβ Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects Gβ in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Gβ, a crucial component of heterotrimeric G proteins, plays a significant role in transmitting signals from cell surface receptors to intracellular effectors, thereby influencing numerous physiological processes. Gβ subunits are essential regulators of G protein alpha subunits and certain signal transduction receptors, which are vital for maintaining cellular communication and response to external stimuli. Notably, Gβ5, one of the five members of the β-subunit family, exhibits unique characteristics, being only 50% homologous to the other β subunits, Gβ1-4, which share at least 83% homology. This distinctiveness is important as Gβ5 is predominantly expressed in the brain, pancreas, kidney, and heart, suggesting specialized functions in these organs. anti-Gβ antibody (F-8) is an invaluable tool for researchers exploring the intricate signaling pathways mediated by G proteins and their implications in health and disease.

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G_β Antibody (F-8) References:

1. G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13).  |  Blake, BL., et al. 2001. J Biol Chem. 276: 49267-74. PMID: 11675383
2. Differential requirement of G alpha12, G alpha13, G alphaq, and G beta gamma for endothelin-1-induced c-Jun NH2-terminal kinase and extracellular signal-regulated kinase activation.  |  Arai, K., et al. 2003. Mol Pharmacol. 63: 478-88. PMID: 12606754
3. Effects of G-protein-specific antibodies and G beta gamma subunits on the muscarinic receptor-operated cation current in guinea-pig ileal smooth muscle cells.  |  Yan, HD., et al. 2003. Br J Pharmacol. 139: 605-15. PMID: 12788820
4. The Emerging Role of Gβ Subunits in Human Genetic Diseases.  |  Malerba, N., et al. 2019. Cells. 8: PMID: 31817184
5. Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels.  |  Reddy, HP., et al. 2021. iScience. 24: 103018. PMID: 34522861
6. G-protein couples MAPK cascade through maize heterotrimeric Gβ subunit.  |  Chen, Y., et al. 2022. Plant Cell Rep. 41: 1763-1774. PMID: 35737098
7. Abscisic acid-controlled redox proteome of Arabidopsis and its regulation by heterotrimeric Gβ protein.  |  Smythers, AL., et al. 2022. New Phytol. 236: 447-463. PMID: 35766993
8. Lumipulse G β-Amyloid Ratio Test for the Diagnosis of Alzheimer Disease.  |  Lau, K. and Lin, KW. 2023. Am Fam Physician. 107: 550-551. PMID: 37192086
9. G beta gamma binds directly to the G protein-gated K+ channel, IKACh.  |  Krapivinsky, G., et al. 1995. J Biol Chem. 270: 29059-62. PMID: 7493925
10. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.  |  Conklin, BR. and Bourne, HR. 1993. Cell. 73: 631-41. PMID: 8388779

The preferred G_β antibody is G_β Antibody (H-1): sc-166123.