Gastric Lipase Antibody (H-1): sc-390750

Gastric Lipase Antibody (H-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Gastric Lipase protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Gastric Lipase antibody (H-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Gastric Lipase, a 379-amino acid protein, plays a vital role in lipid metabolism by hydrolyzing dietary triglycerides in the gastrointestinal tract, particularly in individuals with pancreatic lipase deficiencies. Gastric Lipase is secreted by the fundic mucosa of the stomach and operates optimally under acidic pH conditions, making Gastric Lipase essential for effective digestion. Gastric Lipase′s structure, characterized by high homology to lysosomal acid lipase, enables specific binding and hydrolysis of triglycerides, facilitating nutrient absorption. The lipase gene family, to which Gastric Lipase belongs, encompasses various enzymes integral to lipid metabolism, including Hepatic Lipase, Endothelial Lipase, and Lipoprotein Lipase. Gastric Lipase′s ability to function effectively in the stomach highlights Gastric Lipase′s importance in digestive health and potential implications in metabolic disorders.

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Gastric Lipase Antibody (H-1) References:

1. Enzyme content and acid stability of enteric-coated pancreatic enzyme products in vitro.  |  Case, CL., et al. 2005. Pancreas. 30: 180-3. PMID: 15714141
2. Metabolites of dietary triacylglycerol and diacylglycerol during the digestion process in rats.  |  Osaki, N., et al. 2005. Lipids. 40: 281-6. PMID: 15957254
3. Gastrointestinal lipolysis levels and potential use of gastric lipase in pancreatic insufficiency.  |  Carrière, F. and Laugier, R. 2005. Clin Gastroenterol Hepatol. 3: 715; author reply 716. PMID: 16206507
4. Composite glandular and endocrine tumors of the stomach with pancreatic acinar differentiation.  |  Jain, D., et al. 2005. Am J Surg Pathol. 29: 1524-9. PMID: 16224221
5. Fat taste and lipid metabolism in humans.  |  Mattes, RD. 2005. Physiol Behav. 86: 691-7. PMID: 16249011
6. The metabolism of structured triacylglycerols.  |  Mu, H. and Porsgaard, T. 2005. Prog Lipid Res. 44: 430-48. PMID: 16269186
7. How gastric lipase, an interfacial enzyme with a Ser-His-Asp catalytic triad, acts optimally at acidic pH.  |  Chahinian, H., et al. 2006. Biochemistry. 45: 993-1001. PMID: 16411775
8. Effects of recombinant human gastric lipase and pancreatin during in vitro pediatric gastro-intestinal digestion.  |  Heerup, C., et al. 2021. Food Funct. 12: 2938-2949. PMID: 33710204
9. Coupled secretion of gastric lipase and pepsin in man following pentagastrin stimulation.  |  Szafran, Z., et al. 1978. Digestion. 18: 310-8. PMID: 35435
10. Modulation of gastric lipase adsorption onto mixed galactolipid-phospholipid films by addition of phytosterols.  |  Kergomard, J., et al. 2022. Colloids Surf B Biointerfaces. 220: 112933. PMID: 36279762
11. Value of magnetic resonance cholangiopancreatography with secretin stimulation in the evaluation of pancreatic exocrine function after pancreaticogastrostomy.  |  Shinchi, H., et al. 2004. J Hepatobiliary Pancreat Surg. 11: 50-5. PMID: 15754047
12. Diagnosis and treatment of intestinal malabsorption in cystic fibrosis.  |  Littlewood, JM., et al. 2006. Pediatr Pulmonol. 41: 35-49. PMID: 16288483

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Gastric Lipase Antibody (H-1) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Gastric Lipase Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Gastric Lipase Antibody (H-1) Specifications

Alternate Product Name: Gastric Lipase

Product Clone Name: H-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 296-348

Epitope Target: Gastric Lipase

Epitope Species: mouse

Product Reactivity/Detection: Gastric Lipase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Gastric Lipase Antibody (H-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred LAL antibody is LAL Antibody (9G7F12): sc-58374.