Ganglioside GD3 Antibody (4F6): sc-56112

Ganglioside GD3 Antibody (4F6) is a mouse monoclonal IgG3 antibody that detects Ganglioside GD3 in non-species reactive applications such as immunofluorescence (IF). Ganglioside GD3 is a crucial membrane-bound glycosphingolipid that contains sialic acid and plays a vital role in cell signaling and interaction, particularly in tetraspanin interactions. Ganglioside GD3 is synthesized through the enzymatic action of GD3 Synthase, which transfers sialic acid from CMP-sialic acid to GM3, highlighting its importance in cellular processes. Ganglioside GD3 is predominantly located in the plasma membrane of cells, where Ganglioside GD3 influences cell adhesion and growth, especially in malignant cells. Ganglioside GD3 expression is notably elevated in various pathological conditions, including cancer, where Ganglioside GD3 contributes to the upregulation of tyrosine phosphorylation of key proteins such as p130 Cas and paxillin, thereby promoting tumor progression. Additionally, Ganglioside GD3 plays a significant role in apoptosis regulation, acting as a mediator that can lead to mitochondrial damage, which is critical for determining cell fate. Ganglioside GD3 presence and concentration within a cell can significantly influence survival and response to external stimuli, making Ganglioside GD3 an important target for research in cancer biology and therapeutic interventions.

The preferred Ganglioside GD3 antibody is Ganglioside GD3 Antibody (MB3.6): sc-33685.