Ganglioside GD3 Antibody (MB3.6): sc-33685

Ganglioside GD3 Antibody (MB3.6) is a mouse monoclonal IgG3 kappa light chain antibody that detects Ganglioside GD3 of human origin by immunofluorescence (IF) and flow cytometry (FCM). Anti-Ganglioside GD3 antibody (MB3.6) is available in both conjugated and non-conjugated forms, providing versatility for various experimental needs. Ganglioside GD3 is a crucial glycosphingolipid located in the outer leaflet of the plasma membrane, where Ganglioside GD3 plays a vital role in cell signaling and interaction. Ganglioside GD3 expression is particularly significant in cancer, as Ganglioside GD3 is often overexpressed in malignant cells, contributing to tumor progression and metastasis. The unique structure of Ganglioside GD3, characterized by sialic acid residues, allows participation in important cellular processes such as cell adhesion, migration, and apoptosis regulation. This feature makes Ganglioside GD3 a key player in cancer therapy development, as targeting Ganglioside GD3 may help disrupt signaling pathways that promote tumor growth and survival. Anti-Ganglioside GD3 antibody (MB3.6) detection capabilities in various states of cellular health underscore potential use as a biomarker for disease progression and therapeutic response.

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Ganglioside GD3 Antibody (MB3.6) References:

1. GD3 in cellular ageing and apoptosis.  |  Malisan, F. and Testi, R. 2002. Exp Gerontol. 37: 1273-82. PMID: 12470841
2. Biosignals modulated by tumor-associated carbohydrate antigens: novel targets for cancer therapy.  |  Furukawa, K., et al. 2006. Ann N Y Acad Sci. 1086: 185-98. PMID: 17185516
3. Small cell lung cancer and targeted therapies.  |  Blackhall, FH. and Shepherd, FA. 2007. Curr Opin Oncol. 19: 103-8. PMID: 17272981
4. Overexpression of caveolin-1 in a human melanoma cell line results in dispersion of ganglioside GD3 from lipid rafts and alteration of leading edges, leading to attenuation of malignant properties.  |  Nakashima, H., et al. 2007. Cancer Sci. 98: 512-20. PMID: 17284246
5. Molecular cloning and expression of alpha2,8-sialyltransferase (ST8Sia I, GD3 Synthase) in Xenopus.  |  Rimoldi, S., et al. 2007. Mol Cell Biochem. 301: 143-53. PMID: 17333390
6. Disialoganglioside GD3 increases in the secretion of apoB-containing lipoproteins.  |  Kang, SK., et al. 2007. Biochem Biophys Res Commun. 356: 418-23. PMID: 17368571
7. Inhibition of neuronal migration by JONES antibody is independent of 9-O-acetyl GD3 in GD3-synthase knockout mice.  |  Yang, CR., et al. 2007. J Neurosci Res. 85: 1381-90. PMID: 17385751
8. Neurochemical, morphological, and neurophysiological abnormalities in retinas of Sandhoff and GM1 gangliosidosis mice.  |  Denny, CA., et al. 2007. J Neurochem. 101: 1294-302. PMID: 17442056
9. Protein-chromophore interactions in bacteriorhodopsin: the effects of a change in surface potential.  |  Swords, NA. and Wallace, BA. 1991. Biochim Biophys Acta. 1070: 313-20. PMID: 1764449

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ganglioside GD3 Antibody (MB3.6) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Ganglioside GD3 Antibody (MB3.6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ganglioside GD3 Antibody (MB3.6) Specifications

Alternate Product Name: Ganglioside GD3

Product Clone Name: MB3.6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids:

Epitope Target: GD3

Epitope Species: human

Product Reactivity/Detection: Ganglioside GD3

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Ganglioside GD3 Antibody (MB3.6): FITC: Fluoroscein, PE: Phycoerythrin