Ganglioside GD2 Antibody (11H3): sc-101351
- Ganglioside GD2 Antibody (11H3) is a mouse monoclonal IgG3 provided at 500 µl supernatant
- recommended for detection of Ganglioside GD2 of human origin by WB and ELISA; non cross-reactive with other gangliosides
- See Ganglioside GD2 (14G2a): sc-53831 for Ganglioside GD2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ganglioside GD2 Antibody (11H3). This work is in progress.
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Ganglioside GD2 Antibody (11H3) is a mouse monoclonal IgG3 antibody that detects Ganglioside GD2 of human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-Ganglioside GD2 antibody (11H3) is available in a non-conjugated form, making it suitable for various experimental applications. Ganglioside GD2 is a sialic acid-containing glycosphingolipid that plays a crucial role in cell signaling and cell-cell interactions, which are essential for maintaining cellular communication and tissue integrity. Ganglioside GD2 is predominantly located on the cell surface, where Ganglioside GD2 participates in the formation of the tetraspanin web, a complex network that facilitates interactions between different membrane proteins. Ganglioside GD2 expression is particularly significant in neuroblastoma cells and tumors derived from neuroectoderm, such as malignant melanoma and certain gastrointestinal cancers, highlighting Ganglioside GD2′s potential as a target for immunotherapy. Additionally, Ganglioside GD2 is involved in the regulation of apoptosis through the dephosphorylation of focal adhesion kinases, indicating Ganglioside GD2′s role in cell survival and death pathways. Anti-Ganglioside GD2 antibody (11H3)′s specific recognition capabilities make this antibody a valuable tool for researchers investigating Ganglioside GD2′s function and therapeutic potential in cancer and other diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ganglioside GD2 Antibody (11H3) References:
- Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. | Battula, VL., et al. 2012. J Clin Invest. 122: 2066-78. PMID: 22585577
- Ganglioside GD2 as a therapeutic target for antibody-mediated therapy in patients with osteosarcoma. | Roth, M., et al. 2014. Cancer. 120: 548-54. PMID: 24166473
- Ganglioside GD2 in reception and transduction of cell death signal in tumor cells. | Doronin, II., et al. 2014. BMC Cancer. 14: 295. PMID: 24773917
- Ganglioside GD2 expression is maintained upon recurrence in patients with osteosarcoma. | Poon, VI., et al. 2015. Clin Sarcoma Res. 5: 4. PMID: 25642322
- Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies. | Sterner, E., et al. 2017. Cell Rep. 20: 1681-1691. PMID: 28813678
- Expression of ganglioside GD2, reprogram the lipid metabolism and EMT phenotype in bladder cancer. | Vantaku, V., et al. 2017. Oncotarget. 8: 95620-95631. PMID: 29221154
- Upregulation of Ganglioside GD2 Synthase (GD2S), as a New Putative Cancer Stem Cell Marker in Breast Carcinomas. | Mansoori, M., et al. 2021. Med J Islam Repub Iran. 35: 148. PMID: 35321364
- Extracellular vesicles released from ganglioside GD2-expressing melanoma cells enhance the malignant properties of GD2-negative melanomas. | Yesmin, F., et al. 2023. Sci Rep. 13: 4987. PMID: 36973292
- Establishment of ganglioside GD2-expressing extranodal NK/T-cell lymphoma cell line with scRNA-seq analysis. | Sato, S., et al. 2024. Exp Hematol. 130: 104132. PMID: 38029851
- Ganglioside GD2 Contributes to a Stem-Like Phenotype in Intrahepatic Cholangiocarcinoma. | Mannini, A., et al. 2025. Liver Int. 45: e16208. PMID: 39726234
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ganglioside GD2 Antibody (11H3) | sc-101351 | 500 µl supernatant | $322.00 |