γ1-Adaptin Antibody (C-2): sc-55460

γ1-Adaptin Antibody (C-2) is a mouse monoclonal IgG2a light chain antibody that detects γ1-Adaptin in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). γ1-Adaptin plays a crucial role in the clathrin-mediated endocytosis process, which is essential for the internalization of receptors and other membrane proteins, thereby regulating cellular signaling and nutrient uptake. γ1-Adaptin is primarily located at the plasma membrane and is involved in the formation of clathrin-coated pits, which are vital for the transport of vesicles from the cell surface to the interior. Proper functioning of γ1-Adaptin is important because disruptions in endocytosis can lead to various diseases, including cancer and neurodegenerative disorders. Additionally, γ1-Adaptin interacts with other proteins such as clathrin and adaptin complexes, which further underscores its significance in maintaining cellular homeostasis and facilitating intracellular trafficking. anti-γ1-Adaptin antibody (C-2) is an invaluable tool for researchers studying the mechanisms of endocytosis and related cellular processes.

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γ1-Adaptin Antibody (C-2) References:

1. CD4 downregulation by the HIV-1 protein Nef reveals distinct roles for the γ1 and γ2 subunits of the AP-1 complex in protein trafficking.  |  Tavares, LA., et al. 2017. J Cell Sci. 130: 429-443. PMID: 27909244
2. AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis.  |  Tao, X., et al. 2017. Cancer Lett. 408: 33-42. PMID: 28823958
3. Mechanism of Telapristone Acetate (CDB4124) on Progesterone Receptor Action in Breast Cancer Cells.  |  Davaadelger, B., et al. 2018. Endocrinology. 159: 3581-3595. PMID: 30203004
4. MEG3 promotes liver cancer by activating PI3K/AKT pathway through regulating AP1G1.  |  Sun, Y., et al. 2019. Eur Rev Med Pharmacol Sci. 23: 1459-1467. PMID: 30840267
5. HCP5 promotes colon cancer development by activating AP1G1 via PI3K/AKT pathway.  |  Yun, WK., et al. 2019. Eur Rev Med Pharmacol Sci. 23: 2786-2793. PMID: 31002129
6. A Contemporary Approach to Diagnosis and Treatment of Combined Hepatocellular-Cholangiocarcinoma.  |  Raevskaya, O., et al. 2020. Curr Hepatol Rep. 19: 478-485. PMID: 33415066
7. Identification of methylation-driven genes, circulating miRNAs and their potential regulatory mechanisms in gestational diabetes mellitus.  |  Ju, Y., et al. 2023. Am J Transl Res. 15: 336-349. PMID: 36777869
8. Whole genome sequencing for copy number variant detection to improve diagnosis and management of rare diseases.  |  Bowman, P., et al. 2025. Dev Med Child Neurol. 67: 126-131. PMID: 38840441
9. Identification of a Novel hsa_circ_0058058/miR-324-5p Axis and Prognostic/Predictive Molecules for Acute Myeloid Leukemia Outcome by Bioinformatics-Based Analysis.  |  Misir, S., et al. 2024. Biology (Basel). 13: PMID: 39056681
10. The clathrin adaptor AP1-S1 is associated with immune infiltration and HLA loss, as a potential therapeutic target in lung adenocarcinoma.  |  Liu, Y., et al. 2025. Int Immunopharmacol. 152: 114385. PMID: 40049084

The preferred γ1-Adaptin antibody is γ1-Adaptin Antibody (F-10): sc-398867.