γ-parvin Antibody (A-11): sc-398027

γ-parvin Antibody (A-11) is a mouse monoclonal IgG2b antibody that detects γ-parvin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). γ-parvin is a crucial member of the parvin family, which includes α-parvin and β-parvin, and plays a significant role in linking integrins and associated proteins to intracellular signaling pathways that regulate actin cytoskeletal dynamics and cell survival. γ-parvin is predominantly localized to focal adhesions, where γ-parvin facilitates cell adhesion, spreading, motility, and survival by interacting with key partners such as integrin-linked kinase (ILK), paxillin, α-actinin, and testicular kinase 1. Notably, γ-parvin is essential for establishing cell polarity, which is critical for leukocyte migration, thereby influencing immune responses. The complex formed by γ-parvin and ILK is particularly important for maintaining cell survival in various cell types, including certain cancer cells, kidney podocytes, and cardiac myocytes. With widespread expression in tissues such as skeletal muscle, heart, liver, and kidney, anti-γ-parvin antibody (A-11) serves as a valuable tool for researchers investigating the intricate roles of γ-parvin in cellular processes and disease mechanisms.

The preferred γ-parvin antibody is γ-parvin Antibody (G-8): sc-393593.