γ-parvin Antibody (G-8): sc-393593
- γ-parvin Antibody (G-8) is a mouse monoclonal IgG1 κ γ-parvin antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 50-79 near the N-terminus of γ-parvin of human origin
- gamma-parvin Antibody (G-8) is recommended for detection of γ-parvin of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-gamma-parvin Antibody (G-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for γ-parvin Antibody (G-8) for WB applications. These reagents are now offered in bundles with γ-parvin Antibody (G-8) (see ordering information below).
γ-parvin Antibody (G-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects gamma-parvin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). γ-parvin monoclonal antibody (G-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Gamma-parvin plays a crucial role in linking integrins and associated proteins to intracellular signaling pathways, which are vital for regulating actin cytoskeletal dynamics and promoting cell survival. Gamma-parvin is localized to focal adhesions, where gamma-parvin interacts with key partners such as integrin-linked kinase (ILK), paxillin, α-actinin, and testicular kinase 1, facilitating essential processes like cell adhesion, spreading, motility, and survival. The interaction between gamma-parvin and ILK is critical for establishing cell polarity, which is necessary for effective leukocyte migration, highlighting gamma-parvin′s importance in immune responses and tissue homeostasis. The parvin family, which includes α-parvin, β-parvin, and γ-parvin, is integral to cellular functions, and understanding parvin family roles can provide insights into various physiological and pathological processes, including cancer progression and tissue repair.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
γ-parvin Antibody (G-8) References:
- Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. | Olski, TM., et al. 2001. J Cell Sci. 114: 525-38. PMID: 11171322
- Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. | Korenbaum, E., et al. 2001. Gene. 279: 69-79. PMID: 11722847
- Affixin interacts with alpha-actinin and mediates integrin signaling for reorganization of F-actin induced by initial cell-substrate interaction. | Yamaji, S., et al. 2004. J Cell Biol. 165: 539-51. PMID: 15159419
- Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. | Aboulaich, N., et al. 2004. Biochem J. 383: 237-48. PMID: 15242332
- Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival. | Zhang, Y., et al. 2004. J Biol Chem. 279: 41695-705. PMID: 15284246
- Dysferlin interacts with affixin (beta-parvin) at the sarcolemma. | Matsuda, C., et al. 2005. J Neuropathol Exp Neurol. 64: 334-40. PMID: 15835269
- Formation and phosphorylation of the PINCH-1-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podocyte adhesion, architecture, and survival. | Yang, Y., et al. 2005. J Am Soc Nephrol. 16: 1966-76. PMID: 15872073
- Integrin-linked kinase activity regulates Rac- and Cdc42-mediated actin cytoskeleton reorganization via alpha-PIX. | Filipenko, NR., et al. 2005. Oncogene. 24: 5837-49. PMID: 15897874
- Role of the integrin-linked kinase/PINCH1/alpha-parvin complex in cardiac myocyte hypertrophy. | Chen, H., et al. 2005. Lab Invest. 85: 1342-56. PMID: 16170337
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
γ-parvin Antibody (G-8) | sc-393593 | 200 µg/ml | $322.00 | |||
γ-parvin Antibody (G-8): m-IgG Fc BP-HRP Bundle | sc-530516 | 200 µg Ab; 10 µg BP | $361.00 | |||
γ-parvin Antibody (G-8): m-IgGκ BP-HRP Bundle | sc-524019 | 200 µg Ab, 40 µg BP | $361.00 | |||
γ-parvin Antibody (G-8): m-IgG1 BP-HRP Bundle | sc-544100 | 200 µg Ab; 20 µg BP | $361.00 | |||
γ-parvin Antibody (G-8) AC | sc-393593 AC | 500 µg/ml, 25% agarose | $424.00 | |||
γ-parvin Antibody (G-8) HRP | sc-393593 HRP | 200 µg/ml | $322.00 | |||
γ-parvin Antibody (G-8) FITC | sc-393593 FITC | 200 µg/ml | $336.00 | |||
γ-parvin Antibody (G-8) PE | sc-393593 PE | 200 µg/ml | $349.00 | |||
γ-parvin Antibody (G-8) Alexa Fluor® 488 | sc-393593 AF488 | 200 µg/ml | $364.00 | |||
γ-parvin Antibody (G-8) Alexa Fluor® 546 | sc-393593 AF546 | 200 µg/ml | $364.00 | |||
γ-parvin Antibody (G-8) Alexa Fluor® 594 | sc-393593 AF594 | 200 µg/ml | $364.00 | |||
γ-parvin Antibody (G-8) Alexa Fluor® 647 | sc-393593 AF647 | 200 µg/ml | $364.00 | |||
γ-parvin Antibody (G-8) Alexa Fluor® 680 | sc-393593 AF680 | 200 µg/ml | $364.00 | |||
γ-parvin Antibody (G-8) Alexa Fluor® 790 | sc-393593 AF790 | 200 µg/ml | $364.00 | |||
γ-parvin (G-8) Neutralizing Peptide | sc-393593 P | 100 µg/0.5 ml | $69.00 |