γ-catenin Antibody (D-12): sc-398183

γ-catenin Antibody (D-12) is a mouse monoclonal IgG2a antibody that detects γ-catenin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). γ-catenin, also known as plakoglobin, plays a crucial role in cellular adhesion by forming complexes with cadherins, particularly in adherens junctions. γ-catenin (D-12) antibody targets proteins primarily located in the cytoplasm and cell membrane, where γ-catenin interacts with α-catenin and N-cadherin, facilitating structural integrity of tissues and influencing cell signaling pathways. γ-catenin′s location is essential for maintaining cell-cell adhesion and tissue architecture, which are vital for proper organ function and development. Additionally, γ-catenin′s interaction with other proteins, such as tumor suppressor APC, highlights γ-catenin′s role in cellular signaling and potential implications in cancer biology. Anti-γ-catenin antibody (D-12) enables researchers to gain insights into cell adhesion dynamics and molecular mechanisms underlying various diseases.

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γ-catenin Antibody (D-12) References:

1. Immunoreactive E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin proteins in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, and patients' survival.  |  Endo, K., et al. 2000. Hum Pathol. 31: 558-65. PMID: 10836294
2. Analysis of beta-catenin mutations and alpha-, beta-, and gamma-catenin expression in normal and neoplastic human pituitary tissues.  |  Tziortzioti, V., et al. 2001. Endocr Pathol. 12: 125-36. PMID: 11579678
3. Down-regulation and altered localization of gamma-catenin in cisplatin-resistant adenocarcinoma cells.  |  Liang, XJ., et al. 2004. Mol Pharmacol. 65: 1217-24. PMID: 15102950
4. Functional Loss of the gamma-catenin gene through epigenetic and genetic pathways in human prostate cancer.  |  Shiina, H., et al. 2005. Cancer Res. 65: 2130-8. PMID: 15781623
5. Aberrant activation of gamma-catenin promotes genomic instability and oncogenic effects during tumor progression.  |  Pan, H., et al. 2007. Cancer Biol Ther. 6: 1638-43. PMID: 18245958
6. An EMMPRIN-γ-catenin-Nm23 complex drives ATP production and actomyosin contractility at endothelial junctions.  |  Moreno, V., et al. 2014. J Cell Sci. 127: 3768-81. PMID: 24994937
7. Novel Role for γ-Catenin in the Regulation of Cancer Cell Migration via the Induction of Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1).  |  Sechler, M., et al. 2015. J Biol Chem. 290: 15610-15620. PMID: 25925948
8. MicroRNA-939 governs vascular integrity and angiogenesis through targeting γ-catenin in endothelial cells.  |  Hou, S., et al. 2017. Biochem Biophys Res Commun. 484: 27-33. PMID: 28115160
9. DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway.  |  Sun, C., et al. 2023. Aging (Albany NY). 15: 6380-6399. PMID: 37421607
10. Proteolytic processing of the adherens junctions components beta-catenin and gamma-catenin/plakoglobin during apoptosis.  |  Brancolini, C., et al. 1998. Cell Death Differ. 5: 1042-50. PMID: 9894611

The preferred γ-catenin antibody is γ-catenin Antibody (A-6): sc-514115.