γ-catenin Antibody (15F11): sc-33634

γ-catenin Antibody (15F11) is a mouse monoclonal IgG1 antibody that detects γ-catenin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). γ-catenin, also known as plakoglobin, plays a crucial role in cellular adhesion by forming complexes with cadherins, particularly in adherens junctions. γ-catenin is primarily located in the cytoplasm and at the cell membrane, where γ-catenin interacts with α-catenin and N-cadherin, facilitating structural integrity of tissues and influencing cell signaling pathways. γ-catenin′s location is essential for maintaining cell-cell adhesion and tissue architecture, which are vital for proper organ function and development. γ-catenin′s association with other proteins, such as transmembrane phosphatase PTPµ, suggests a role in regulating signaling pathways critical for cellular responses to external stimuli. Anti-γ-catenin antibody (15F11) serves as an invaluable tool for researchers studying cell adhesion dynamics and molecular mechanisms underlying various diseases, including cancer, where dysregulation of cadherin-catenin complexes can lead to increased invasiveness and metastasis.

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γ-catenin Antibody (15F11) References:

1. gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.  |  Kolligs, FT., et al. 2000. Genes Dev. 14: 1319-31. PMID: 10837025
2. Immunohistochemical analysis of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin, and neural cell adhesion molecule (NCAM) in chordoma.  |  Naka, T., et al. 2001. J Clin Pathol. 54: 945-50. PMID: 11729215
3. Prognostic and clinicopathological features of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin and cyclin D1 expression in human esophageal squamous cell carcinoma.  |  Lin, YC., et al. 2004. World J Gastroenterol. 10: 3235-9. PMID: 15484291
4. Upregulation of gamma-catenin compensates for the loss of beta-catenin in adult cardiomyocytes.  |  Zhou, J., et al. 2007. Am J Physiol Heart Circ Physiol. 292: H270-6. PMID: 16936006
5. Expression of adhesion proteins E-cadherin, alpha-catenin, beta-catenin and gamma-catenin is different in T1 and T2 breast tumours.  |  Bukholm, IR., et al. 2006. Pathology. 38: 403-7. PMID: 17008277
6. Hepatocyte γ-catenin compensates for conditionally deleted β-catenin at adherens junctions.  |  Wickline, ED., et al. 2011. J Hepatol. 55: 1256-62. PMID: 21703193
7. γ-Catenin at adherens junctions: mechanism and biologic implications in hepatocellular cancer after β-catenin knockdown.  |  Wickline, ED., et al. 2013. Neoplasia. 15: 421-34. PMID: 23555187
8. Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation.  |  Mahendram, S., et al. 2013. PLoS One. 8: e65320. PMID: 23724138
9. γ-Catenin Overexpression in AML Patients May Promote Tumor Cell Survival via Activation of the Wnt/β-Catenin Axis.  |  Qian, J., et al. 2020. Onco Targets Ther. 13: 1265-1276. PMID: 32103994
10. Cleavage of Desmosomal Cadherins Promotes γ-Catenin Degradation and Benefits Wnt Signaling in Coxsackievirus B3-Induced Destruction of Cardiomyocytes.  |  Zhao, G., et al. 2020. Front Microbiol. 11: 767. PMID: 32457708

The preferred γ-catenin antibody is γ-catenin Antibody (A-6): sc-514115.