γ-Actin Antibody (2-2): sc-65636
- γ-Actin Antibody (2-2) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised aginast cytoplasmic γ-Actin from brain tissue of bovine origin
- recommended for detection of γ-Actin of mouse, rat and human origin by WB, IP, IF and IHC(P); also reactive with additional species, including bovine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for γ-Actin Antibody (2-2) for WB and IHC(P) applications. These reagents are now offered in bundles with γ-Actin Antibody (2-2) (see ordering information below).
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γ-Actin Antibody (2-2) is a mouse monoclonal IgG1 antibody that detects γ-Actin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. γ-Actin plays a vital role in the structural integrity and motility of cells, as a key component of the cytoskeleton, which provides shape and support while facilitating movement and division. γ-Actin is predominantly found in non-muscle cells, where γ-Actin contributes to various cellular processes, including cell shape maintenance, intracellular transport, and cell signaling. γ-Actin in the cytoplasm is crucial for the formation of lamellipodia and filopodia, which are essential for cell migration and tissue development. γ-Actin interacts with a variety of proteins, including myosin and tropomyosin, which are important for muscle contraction and cellular movement. Dynamic structures formed by γ-Actin allow cells to respond to environmental cues, making anti-γ-Actin antibody (2-2) an invaluable tool for researchers investigating cellular processes and various pathologies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
γ-Actin Antibody (2-2) References:
- The golgi-associated COPI-coated buds and vesicles contain beta/gamma -actin. | Valderrama, F., et al. 2000. Proc Natl Acad Sci U S A. 97: 1560-5. PMID: 10677499
- beta- and gamma-actin genes differ in their mechanisms of down-regulation during myogenesis. | Lloyd, C. and Gunning, P. 2002. J Cell Biochem. 84: 335-42. PMID: 11787062
- Smooth muscle gamma-actin promoter regulation by RhoA and serum response factor signaling. | Carson, JA., et al. 2003. Biochim Biophys Acta. 1628: 133-9. PMID: 12890560
- Transfection of nonmuscle beta- and gamma-actin genes into myoblasts elicits different feedback regulatory responses from endogenous actin genes. | Lloyd, C., et al. 1992. J Cell Biol. 117: 787-97. PMID: 1577858
- Allele-specific effects of human deafness gamma-actin mutations (DFNA20/26) on the actin/cofilin interaction. | Bryan, KE. and Rubenstein, PA. 2009. J Biol Chem. 284: 18260-9. PMID: 19419963
- Hydroxyapatite-coated sillicone rubber enhanced cell adhesion and it may be through the interaction of EF1β and γ-actin. | Shi, XH., et al. 2014. PLoS One. 9: e111503. PMID: 25386892
- Involvement of β- and γ-actin isoforms in actin cytoskeleton organization and migration abilities of bleb-forming human colon cancer cells. | Simiczyjew, A., et al. 2017. PLoS One. 12: e0173709. PMID: 28333953
- Genomic Amplification and Functional Dependency of the Gamma Actin Gene ACTG1 in Uterine Cancer. | Richter, C., et al. 2020. Int J Mol Sci. 21: PMID: 33217970
- Subcellular sorting of isoactins: selective association of gamma actin with skeletal muscle mitochondria. | Pardo, JV., et al. 1983. Cell. 32: 1093-103. PMID: 6340835
- Enhancement of gamma-actin protein during liver regeneration: its accumulation in a region adjacent to the hepatocyte plasma membrane. | Tanahashi, T., et al. 1995. J Biochem. 118: 355-63. PMID: 8543570
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
γ-Actin Antibody (2-2) | sc-65636 | 200 µg/ml | $322.00 | |||
γ-Actin Antibody (2-2): m-IgG Fc BP-HRP Bundle | sc-537176 | 200 µg Ab; 10 µg BP | $361.00 | |||
γ-Actin Antibody (2-2): m-IgGκ BP-HRP Bundle | sc-534376 | 200 µg Ab; 40 µg BP | $361.00 | |||
γ-Actin Antibody (2-2): m-IgG1 BP-HRP Bundle | sc-545056 | 200 µg Ab; 20 µg BP | $361.00 |