γ-Actin Antibody (1-37): sc-65637

γ-Actin Antibody (1-37) is a mouse monoclonal IgG1 antibody that detects γ-Actin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-γ-Actin antibody (1-37) recognizes a crucial component of the cytoskeleton, playing a vital role in maintaining cell shape, enabling cellular motility, and facilitating intracellular transport. γ-Actin is predominantly found in non-muscle cells, where γ-Actin contributes to the formation of various structures, including lamellipodia and filopodia, which are essential for cell migration and signaling. γ-Actin (1-37) monoclonal antibody helps researchers study these structures, underscoring their importance in processes such as wound healing and immune responses, where rapid cell movement is necessary. γ-Actin interacts with a variety of proteins, including profilin and cofilin, which are involved in actin polymerization and depolymerization, respectively. These interactions are critical for the dynamic remodeling of the actin cytoskeleton, allowing cells to adapt to their environment and respond to external stimuli effectively. Anti-γ-Actin antibody (1-37) serves as an invaluable tool for researchers studying the intricate roles of actin in cellular processes and its implications in various diseases.

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γ-Actin Antibody (1-37) References:

1. Ca(2+) activation and tension cost in myofilaments from mouse hearts ectopically expressing enteric gamma-actin.  |  Martin, AF., et al. 2002. Am J Physiol Heart Circ Physiol. 283: H642-9. PMID: 12124211
2. A novel role for non-muscle gamma-actin in skeletal muscle sarcomere assembly.  |  Lloyd, CM., et al. 2004. Exp Cell Res. 297: 82-96. PMID: 15194427
3. High level expression of transfected beta- and gamma-actin genes differentially impacts on myoblast cytoarchitecture.  |  Schevzov, G., et al. 1992. J Cell Biol. 117: 775-85. PMID: 1577857
4. Effect of overexpression of β- and γ-actin isoforms on actin cytoskeleton organization and migration of human colon cancer cells.  |  Simiczyjew, A., et al. 2014. Histochem Cell Biol. 142: 307-22. PMID: 24682235
5. Differential roles of α-, β-, and γ-actin in axon growth and collateral branch formation in motoneurons.  |  Moradi, M., et al. 2017. J Cell Biol. 216: 793-814. PMID: 28246119
6. The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins.  |  Greve, JN., et al. 2024. Elife. 12: PMID: 38446501
7. Thiazole-fused androstenone and ethisterone derivatives: potent β- and γ-actin cytoskeleton inhibitors to treat melanoma tumors.  |  Adhikary, S., et al. 2024. RSC Med Chem.. PMID: 39703801
8. β-actin function in platelets and red blood cells can be performed by γ-actin and is therefore independent of actin isoform protein sequence.  |  Chakravarty, D., et al. 2025. Mol Biol Cell. 36: ar18. PMID: 39705375
9. Noncoding regions of the gamma-actin gene influence the impact of the gene on myoblast morphology.  |  Lloyd, C. and Gunning, P. 1993. J Cell Biol. 121: 73-82. PMID: 8458874
10. Regulation of beta- and gamma-actin mRNA by thyroid hormone in the developing rat brain.  |  Sarkar, S., et al. 1997. Neuroreport. 8: 1267-71. PMID: 9175127

The preferred γ-Actin antibody is γ-Actin Antibody (1-17): sc-65638.