γ-Actin Antibody (1-24): sc-65635
- γ-Actin Antibody (1-24) is a mouse monoclonal IgG1 κ, cited in 8 publications, provided at 200 µg/ml
- raised against cytoplasmic γ-Actin from brain tissue of bovine origin
- recommended for detection of γ Actin of mouse, rat and human origin by WB, IP and IF
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for γ-Actin Antibody (1-24) for WB applications. These reagents are now offered in bundles with γ-Actin Antibody (1-24) (see ordering information below).
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γ-Actin Antibody (1-24) is a mouse monoclonal IgG1 antibody that detects γ-Actin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). γ-Actin is a crucial component of the cytoskeleton, playing a vital role in maintaining cell shape, enabling cellular motility, and facilitating intracellular transport. Anti-γ-Actin antibody (1-24) recognizes a protein predominantly found in non-muscle cells, where γ-Actin contributes to the formation of the actin filament network, essential for various cellular processes, including cell division and signal transduction. γ-Actin in the cytoplasm allows for dynamic remodeling of the cytoskeleton, which is critical for processes such as wound healing and immune responses. γ-Actin interacts with a variety of proteins, including myosin, which is essential for muscle contraction and cellular movement, highlighting γ-Actin′s importance in both structural integrity and functional dynamics of cells. Anti-γ-Actin antibody (1-24) serves as an invaluable tool for researchers studying the actin cytoskeleton and its implications in health and disease.
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γ-Actin Antibody (1-24) References:
- Mutations in the gamma-actin gene (ACTG1) are associated with dominant progressive deafness (DFNA20/26). | Zhu, M., et al. 2003. Am J Hum Genet. 73: 1082-91. PMID: 13680526
- Effects of human deafness gamma-actin mutations (DFNA20/26) on actin function. | Bryan, KE., et al. 2006. J Biol Chem. 281: 20129-39. PMID: 16690605
- Cytoplasmic gamma-actin is not required for skeletal muscle development but its absence leads to a progressive myopathy. | Sonnemann, KJ., et al. 2006. Dev Cell. 11: 387-97. PMID: 16950128
- Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia. | Verrills, NM., et al. 2006. J Natl Cancer Inst. 98: 1363-74. PMID: 17018783
- Cytoplasmic gamma-actin expression in diverse animal models of muscular dystrophy. | Hanft, LM., et al. 2007. Neuromuscul Disord. 17: 569-74. PMID: 17475492
- Evidence for gamma-actin as a Z disc component in skeletal myofibers. | Papponen, H., et al. 2009. Exp Cell Res. 315: 218-25. PMID: 19013151
- Nonredundant roles of cytoplasmic β- and γ-actin isoforms in regulation of epithelial apical junctions. | Baranwal, S., et al. 2012. Mol Biol Cell. 23: 3542-53. PMID: 22855531
- Partial depletion of gamma-actin suppresses microtubule dynamics. | Po'uha, ST., et al. 2013. Cytoskeleton (Hoboken). 70: 148-60. PMID: 23335583
- Gamma-actin is involved in regulating centrosome function and mitotic progression in cancer cells. | Po'uha, ST. and Kavallaris, M. 2015. Cell Cycle. 14: 3908-19. PMID: 26697841
- Interaction of microtubules with the actin cytoskeleton via cross-talk of EB1-containing +TIPs and γ-actin in epithelial cells. | Dugina, V., et al. 2016. Oncotarget. 7: 72699-72715. PMID: 27683037
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
γ-Actin Antibody (1-24) | sc-65635 | 200 µg/ml | $316.00 | |||
γ-Actin Antibody (1-24): m-IgG Fc BP-HRP Bundle | sc-537175 | 200 µg Ab; 10 µg BP | $354.00 | |||
γ-Actin Antibody (1-24): m-IgGκ BP-HRP Bundle | sc-534375 | 200 µg Ab; 40 µg BP | $354.00 | |||
γ-Actin Antibody (1-24): m-IgG1 BP-HRP Bundle | sc-545055 | 200 µg Ab; 20 µg BP | $354.00 |