G_{α q/11/14} Antibody (G-7): sc-365906

Gα q/11/14 Antibody (G-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects G alpha q/11/14 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Gα q/11/14 (G-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. G alpha q/11/14 protein plays a crucial role in cellular signaling as a member of the heterotrimeric G protein family, which transmits signals from activated receptors on the cell surface to intracellular effectors. Specifically, G alpha q/11/14 proteins are involved in the activation of phospholipase C, leading to the production of inositol trisphosphate and diacylglycerol, which are vital for calcium signaling and various cellular responses. This signaling pathway is essential for numerous physiological processes, including muscle contraction, neurotransmitter release, and cell proliferation. G alpha q/11/14 proteins are particularly abundant in the brain and lungs, where these proteins mediate responses to a variety of extracellular signals, highlighting their importance in both central nervous system function and respiratory physiology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

G_{α q/11/14} Antibody (G-7) References:

1. Opioid receptor signalling mechanisms.  |  Connor, M. and Christie, MD. 1999. Clin Exp Pharmacol Physiol. 26: 493-9. PMID: 10405772
2. Selective tissue distribution of G protein gamma subunits, including a new form of the gamma subunits identified by cDNA cloning.  |  Cali, JJ., et al. 1992. J Biol Chem. 267: 24023-7. PMID: 1385432
3. Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.  |  von Weizsäcker, E., et al. 1992. Biochem Biophys Res Commun. 183: 350-6. PMID: 1543505
4. Gustducin is a taste-cell-specific G protein closely related to the transducins.  |  McLaughlin, SK., et al. 1992. Nature. 357: 563-9. PMID: 1608467
5. Diversity of G proteins in signal transduction.  |  Simon, MI., et al. 1991. Science. 252: 802-8. PMID: 1902986
6. G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates.  |  Strathmann, M. and Simon, MI. 1990. Proc Natl Acad Sci U S A. 87: 9113-7. PMID: 2123549
7. Unusual phototransduction via cross-motif signaling from Gq to adenylyl cyclase in intrinsically photosensitive retinalganglion cells.  |  Chen, L., et al. 2023. Proc Natl Acad Sci U S A. 120: e2216599120. PMID: 36584299
8. The role of Gαq in regulating NLRP3 inflammasome activation.  |  Kong, R., et al. 2024. Inflamm Res. 73: 2249-2261. PMID: 39455437
9. Characterization of Gq family G proteins GL1 alpha (G14 alpha), GL2 alpha (G11 alpha), and Gq alpha expressed in the baculovirus-insect cell system.  |  Nakamura, F., et al. 1995. J Biol Chem. 270: 6246-53. PMID: 7890762
10. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors.  |  Conklin, BR. and Bourne, HR. 1993. Cell. 73: 631-41. PMID: 8388779
11. Importance of N-terminal regions of G protein alpha subunits for the activation of phospholipase C in Xenopus oocytes.  |  Nakamura, K., et al. 1996. J Biochem. 120: 996-1001. PMID: 8982868
12. Evidence that Gq family G proteins do not function in mouse egg activation at fertilization.  |  Williams, CJ., et al. 1998. Dev Biol. 198: 116-27. PMID: 9640335

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-G_{α q/11/14} Antibody (G-7) has 24 citations in a variety of scientific publications.

Primary antibodies like Anti-G_{α q/11/14} Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

G_{α q/11/14} Antibody (G-7) Specifications

Alternate Product Name: G-protein subunit GNAQ/ GNA11/ GNA14

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 60-359

Epitope Target: Gα 11

Epitope Species: human

Product Reactivity/Detection: G_{α q}, G_{α 11} and G_{α 14}

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 24 citations in various scientific publications

Available Conjugates/Forms for G_{α q/11/14} Antibody (G-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred G_{α q} antibody is G_{α q} Antibody (10): sc-136181.