galectin-5 Antibody (F-11): sc-48358

galectin-5 Antibody (F-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects galectin-5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-galectin-5 antibody (F-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Galectin-5, also known as RL-18, is a member of the galectin family, which consists of soluble β-galactoside-binding lectins that play crucial roles in cell adhesion, extracellular matrix interactions, and various biological processes such as tumor progression and apoptosis. Notably, galectin-5 is predominantly expressed in erythrocytes, where galectin-5 is believed to be involved in erythrocyte differentiation, a critical process for maintaining proper blood function and oxygen transport. Galectin-5 exists as a monomer and shares significant homology with the C-terminal domain of galectin-9, which is known for its role in immune responses and inflammation. Understanding galectin-5 function is essential, as galectin-5 may provide insights into potential therapeutic applications in hematological disorders and cancer biology.

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galectin-5 Antibody (F-11) References:

1. Signature sequences for the galectin-4 subfamily.  |  Jiang, W., et al. 1999. IUBMB Life. 48: 601-5. PMID: 10683764
2. Interaction profile of galectin-5 with free saccharides and mammalian glycoproteins: probing its fine specificity and the effect of naturally clustered ligand presentation.  |  Wu, AM., et al. 2006. Glycobiology. 16: 524-37. PMID: 16540530
3. Unique sequence and expression profiles of rat galectins-5 and -9 as a result of species-specific gene divergence.  |  Lensch, M., et al. 2006. Int J Biochem Cell Biol. 38: 1741-58. PMID: 16740401
4. Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages.  |  Barrès, C., et al. 2010. Blood. 115: 696-705. PMID: 19903899
5. Reticulocyte membrane remodeling: contribution of the exosome pathway.  |  Blanc, L. and Vidal, M. 2010. Curr Opin Hematol. 17: 177-83. PMID: 20173636
6. Exosomal membrane molecules are potent immune response modulators.  |  Anand, PK. 2010. Commun Integr Biol. 3: 405-8. PMID: 21057626
7. Galectins and microenvironmental niches during hematopoiesis.  |  Rabinovich, GA. and Vidal, M. 2011. Curr Opin Hematol. 18: 443-51. PMID: 21912250
8. Structural Characterization of Rat Galectin-5, an N-Tailed Monomeric Proto-Type-like Galectin.  |  Ruiz, FM., et al. 2021. Biomolecules. 11: PMID: 34944498
9. Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing.  |  Van Eynde, A., et al. 1995. J Biol Chem. 270: 28068-74. PMID: 7499293
10. Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes.  |  Gitt, MA., et al. 1995. J Biol Chem. 270: 5032-8. PMID: 7890611
11. Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin.  |  Wada, J. and Kanwar, YS. 1997. J Biol Chem. 272: 6078-86. PMID: 9038233
12. Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease.  |  Türeci, O., et al. 1997. J Biol Chem. 272: 6416-22. PMID: 9045665

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-galectin-5 Antibody (F-11) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-galectin-5 Antibody (F-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

galectin-5 Antibody (F-11) Specifications

Alternate Product Name: galectin-5

Product Clone Name: F-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-145

Epitope Target: galectin-5

Epitope Species: rat

Product Reactivity/Detection: galectin-5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for galectin-5 Antibody (F-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin