galectin-4 Antibody (B-9): sc-271533

galectin-4 Antibody (B-9) is a mouse monoclonal IgG2a antibody that detects galectin-4 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Galectin-4, also known as Gal-4, L36, or LGALS4, is a member of the galectin family, which consists of soluble β-galactoside-binding lectins that play crucial roles in various biological processes, including cell adhesion, tumor progression, and apoptosis. Galectin-4 is composed of 323 amino acids and features two homologous carbohydrate recognition domains, which are essential for binding activity and functional versatility. Notably, galectin-4 is primarily expressed in epithelial cells of the colon, rectum, and intestine, and expression levels are closely associated with the malignant potential of human hepatocellular carcinoma. Galectin-4 undergoes differential regulation based on factors such as cell-cell contact and serum growth factors, which can influence cellular processes. Anti-galectin-4 antibody (B-9) is particularly valuable in research focused on colorectal cancer, where galectin-4 is often underexpressed, and in studies examining upregulation in cells prone to peritoneal dissemination. With robust performance in various applications, galectin-4 (B-9) antibody serves as an essential tool for researchers investigating the complex roles of galectin-4 in health and disease.

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galectin-4 Antibody (B-9) References:

1. Role of the carbohydrate recognition domains of mouse galectin-4 in oligosaccharide binding and epitope recognition and expression of galectin-4 and galectin-6 in mouse cells and tissues.  |  Marková, V., et al. 2006. Int J Mol Med. 18: 65-76. PMID: 16786157
2. Galectin-4 is involved in p27-mediated activation of the myelin basic protein promoter.  |  Wei, Q., et al. 2007. J Neurochem. 101: 1214-23. PMID: 17403142
3. Galectin-4, a novel neuronal regulator of myelination.  |  Stancic, M., et al. 2012. Glia. 60: 919-35. PMID: 22431161
4. Neuronal Galectin-4 is required for axon growth and for the organization of axonal membrane L1 delivery and clustering.  |  Velasco, S., et al. 2013. J Neurochem. 125: 49-62. PMID: 23311731
5. Abrogation of galectin-4 expression promotes tumorigenesis in colorectal cancer.  |  Kim, SW., et al. 2013. Cell Oncol (Dordr). 36: 169-78. PMID: 23378274
6. Phosphorylation and externalization of galectin-4 is controlled by Src family kinases.  |  Ideo, H., et al. 2013. Glycobiology. 23: 1452-62. PMID: 24013903
7. Neurons define non-myelinated axon segments by the regulation of galectin-4-containing axon membrane domains.  |  Díez-Revuelta, N., et al. 2017. Sci Rep. 7: 12246. PMID: 28947766
8. Galectin-4, a Negative Regulator of Oligodendrocyte Differentiation, Is Persistently Present in Axons and Microglia/Macrophages in Multiple Sclerosis Lesions.  |  de Jong, CGHM., et al. 2018. J Neuropathol Exp Neurol. 77: 1024-1038. PMID: 30252090
9. High expression of B3GALT5 suppresses the galectin-4-mediated peritoneal dissemination of poorly differentiated gastric cancer cells.  |  Tsuchida, A., et al. 2024. Glycobiology. 34: PMID: 39163480
10. Galectin-4 and galectin-6 are two closely related lectins expressed in mouse gastrointestinal tract.  |  Gitt, MA., et al. 1998. J Biol Chem. 273: 2954-60. PMID: 9446608

The preferred galectin-4 antibody is galectin-4 Antibody (E-2): sc-271209.