galectin-3 Antibody (H-5): sc-374253
- galectin-3 Antibody (H-5) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-31 at the N-terminus of galectin-3 of human origin
- recommended for detection of galectin-3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See galectin-3 (B2C10): sc-32790 for galectin-3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for galectin-3 Antibody (H-5) for WB and IHC(P) applications. These reagents are now offered in bundles with galectin-3 Antibody (H-5) (see ordering information below).
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SEE ALSO...
galectin-3 Antibody (H-5) is a mouse monoclonal IgG1 kappa light chain antibody designed to target galectin-3, also known as Mac-2, hMac-2 (human Mac-2), GALBP (galactose-binding protein), CBP35 (carbohydrate-binding protein 35), and LGALS3 (lectin, galactoside-binding, soluble, 3). anti-galectin-3 antibody (H-5) recognizes an epitope between amino acids 2-31 at the N-terminus of human galectin-3 and is validated for detecting galectin-3 in mouse, rat, and human samples using western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Galectin-3 is a key member of the galectin family of soluble β-galactoside-binding lectins, playing a crucial role in regulating cell-to-cell adhesion and interactions with the extracellular matrix (ECM). These functions are essential for processes such as tissue development, immune responses, and cellular communication. Galectin-3 is involved in tumor progression and metastasis by promoting cancer cell proliferation, resisting apoptosis, and facilitating angiogenesis. Additionally, galectin-3 plays a role in pre-mRNA splicing and apoptosis, contributing to cellular homeostasis and the response to stress. Galectin-3 interacts with various proteins, including β1 integrins, epidermal growth factor receptor (EGFR), and members of the Bcl-2 family, which are important for cell adhesion, proliferation, and survival. The expression of galectin-3 is prominent in colonic and intestinal epithelial cells, inflammatory macrophages, various carcinomas, neoplastic astrocytes, and certain lymphocytes. Elevated levels of galectin-3 are associated with enhanced cancer progression, thyroid malignancies, and Crohn′s disease, making galectin-3 a valuable diagnostic marker for conditions such as Hurthle cell adenomas and carcinomas. galectin-3 (H-5) monoclonal antibody is available in both non-conjugated and various conjugated forms, including horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and Alexa Fluor® conjugates, providing versatile options for diverse research applications.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
galectin-3 Antibody (H-5) | sc-374253 | 200 µg/ml | $322.00 | |||
galectin-3 Antibody (H-5): m-IgG Fc BP-HRP Bundle | sc-537944 | 200 µg Ab; 10 µg BP | $361.00 | |||
galectin-3 Antibody (H-5): m-IgGκ BP-HRP Bundle | sc-535429 | 200 µg Ab; 40 µg BP | $361.00 | |||
galectin-3 Antibody (H-5): m-IgG1 BP-HRP Bundle | sc-545463 | 200 µg Ab; 20 µg BP | $361.00 | |||
galectin-3 (H-5) Neutralizing Peptide | sc-374253 P | 100 µg/0.5 ml | $69.00 |