galectin-3 Antibody (A3A12): sc-53127
- galectin-3 Antibody (A3A12) is a mouse monoclonal IgG1 κ, cited in 18 publications, provided at 200 µg/ml
- raised against recombinant full length human galectin-3
- Anti-galectin-3 Antibody (A3A12) is recommended for detection of galectin-3 of mouse, rat and human origin by WB, IP, IF, IHC(P), FCM and ELISA
- Anti-galectin-3 Antibody (A3A12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for galectin-3 Antibody (A3A12) for WB and IHC(P) applications. These reagents are now offered in bundles with galectin-3 Antibody (A3A12) (see ordering information below).
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SEE ALSO...
galectin-3 Antibody (A3A12) is a mouse monoclonal IgG1 kappa light chain antibody designed to target galectin-3, also known by its alternate names Mac-2, hMac-2 (human Mac-2), GALBP (galactose-binding protein), CBP35 (carbohydrate-binding protein 35), and LGALS3 (lectin, galactoside-binding, soluble, 3). anti-galectin-3 antibody (A3A12) is raised against recombinant full-length human galectin-3 and is recommended for the detection of galectin-3 in mouse, rat, and human samples using a variety of applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Galectin-3 is a member of the galectin family of soluble β-galactoside-binding lectins characterized by a single carbohydrate recognition domain (CRD) that is crucial for binding to galactose-containing glycoconjugates. Structurally, galectin-3 can exist in both monomeric and oligomeric forms, allowing galectin-3 to engage in diverse interactions that are essential for modulating cell-to-cell adhesion, cell-to-extracellular matrix (ECM) interactions, and various cellular signaling pathways. Post-translational modifications of galectin-3, such as phosphorylation and oxidation, play a vital role in regulating function, stability, and localization within the cell, thereby influencing processes like apoptosis, immune responses, and cancer progression. These modifications can alter galectin-3′s ability to interact with other proteins and carbohydrates, thereby affecting cellular homeostasis and disease states. Upregulated expression of galectin-3 is closely associated with enhanced cancer progression and metastasis, thyroid malignancies, and Crohn′s disease, and serves as a valuable diagnostic marker for conditions such as Hurthle cell adenomas and carcinomas. galectin-3 (A3A12) antibody is available in both non-conjugated form and a variety of conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
galectin-3 Antibody (A3A12) | sc-53127 | 200 µg/ml | $322.00 | |||
galectin-3 Antibody (A3A12): m-IgG Fc BP-HRP Bundle | sc-528551 | 200 µg Ab; 10 µg BP | $361.00 | |||
galectin-3 Antibody (A3A12): m-IgGκ BP-HRP Bundle | sc-520950 | 200 µg Ab, 40 µg BP | $361.00 | |||
galectin-3 Antibody (A3A12): m-IgG1 BP-HRP Bundle | sc-542989 | 200 µg Ab; 20 µg BP | $361.00 | |||
galectin-3 Antibody (A3A12) AC | sc-53127 AC | 500 µg/ml, 25% agarose | $424.00 | |||
galectin-3 Antibody (A3A12) HRP | sc-53127 HRP | 200 µg/ml | $322.00 | |||
galectin-3 Antibody (A3A12) FITC | sc-53127 FITC | 200 µg/ml | $336.00 | |||
galectin-3 Antibody (A3A12) PE | sc-53127 PE | 200 µg/ml | $349.00 | |||
galectin-3 Antibody (A3A12) Alexa Fluor® 488 | sc-53127 AF488 | 200 µg/ml | $364.00 | |||
galectin-3 Antibody (A3A12) Alexa Fluor® 546 | sc-53127 AF546 | 200 µg/ml | $364.00 | |||
galectin-3 Antibody (A3A12) Alexa Fluor® 594 | sc-53127 AF594 | 200 µg/ml | $364.00 | |||
galectin-3 Antibody (A3A12) Alexa Fluor® 647 | sc-53127 AF647 | 200 µg/ml | $364.00 | |||
galectin-3 Antibody (A3A12) Alexa Fluor® 680 | sc-53127 AF680 | 200 µg/ml | $364.00 | |||
galectin-3 Antibody (A3A12) Alexa Fluor® 790 | sc-53127 AF790 | 200 µg/ml | $364.00 |