galectin-1 Antibody (E-2): sc-166619

Galectin-1 Antibody (E-2) is a mouse monoclonal IgG2b antibody that detects galectin-1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Galectin-1, also known as LGALS1, is a critical protein that plays a significant role in regulating cell proliferation, particularly in maintaining the G0 phase and controlling the transition through G2, which is essential for proper cell cycle progression. Anti-galectin-1 antibody (E-2) recognizes a protein encoded by a single gene located on human chromosome 22q13.1 and consists of 135 amino acids, featuring a single internal EcoRI site and a polyadenylation signal. Galectin-1 localizes in both intracellular and extracellular environments, which is vital for modulating cell-to-cell adhesion and interactions with the extracellular matrix. Expression of galectin-1 is observed in various human tissues and cell lines, including the placenta, lung, HL-6, HepG2, and CEM cells, highlighting its importance in diverse biological processes and potential implications in tumor progression and apoptosis. Galectin-1 (E-2) antibody provides a reliable tool for researchers investigating the multifaceted roles of galectin-1 in cellular functions and disease mechanisms.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

Download thiomersal SDS

galectin-1 Antibody (E-2) References:

1. Prognostic significance of galectin-1 expression in patients with cancer: a meta-analysis.  |  Wu, R., et al. 2018. Cancer Cell Int. 18: 108. PMID: 30087582
2. Human Galectin-1 and Its Inhibitors: Privileged Target for Cancer and HIV.  |  Goud, NS., et al. 2019. Mini Rev Med Chem. 19: 1369-1378. PMID: 30834831
3. Galectin-1 studies in proliferative diabetic retinopathy.  |  Abu El-Asrar, AM., et al. 2020. Acta Ophthalmol. 98: e1-e12. PMID: 31318490
4. Human galectin-1 and galectin-3 promote Tropheryma whipplei infection.  |  Ayona, D., et al. 2021. Gut Microbes. 13: 1-15. PMID: 33573443
5. Human Galectin-1 in Multiple Cancers: A Privileged Molecular Target in Oncology.  |  Goud, NS. and Bhattacharya, A. 2021. Mini Rev Med Chem. 21: 2169-2186. PMID: 33596802
6. Galectin-1 activates carbonic anhydrase IX and modulates glioma metabolism.  |  Guda, MR., et al. 2022. Cell Death Dis. 13: 574. PMID: 35773253
7. Circulating galectin-1 delineates response to bevacizumab in melanoma patients and reprograms endothelial cell biology.  |  Bannoud, N., et al. 2023. Proc Natl Acad Sci U S A. 120: e2214350120. PMID: 36634146
8. Inhibition of Galectin-1 attenuates lung fibroblast activation and proliferation in lung fibrosis.  |  Xue, J. and Li, S. 2023. Cell Mol Biol (Noisy-le-grand). 69: 213-218. PMID: 38015516
9. Discovery of Selective and Orally Available Galectin-1 Inhibitors.  |  Zetterberg, FR., et al. 2023. J Med Chem. 66: 16980-16990. PMID: 38059452
10. Targeting Galectin-1 Overcomes Paclitaxel Resistance in Esophageal Squamous Cell Carcinoma.  |  Zhou, L., et al. 2024. Cancer Res. 84: 3894-3908. PMID: 39186691

The preferred galectin-1 antibody is galectin-1 Antibody (C-8): sc-166618.