galectin-1 Antibody (C-8): sc-166618

galectin-1 Antibody (C-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects galectin-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-galectin-1 antibody (C-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Galectin-1, also known as LGALS1, plays a significant role in modulating cell-to-cell adhesion and interactions with the extracellular matrix, which are essential for maintaining tissue architecture and facilitating cellular communication. galectin-1 (C-8) antibody targets a protein that influences cell proliferation and apoptosis, affecting cancer development and metastasis. Galectin-1 consists of 135 amino acids and is encoded by a gene located on human chromosome 22q13.1, featuring a single internal EcoRI site and a polyadenylation signal. Galectin-1 is expressed in various tissues, including human placenta and lung, as well as in cell lines such as HL-6, HepG2, and CEM, and can localize to both intracellular and extracellular spaces, highlighting its versatile role in cellular processes.

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galectin-1 Antibody (C-8) References:

1. Expression of endogenous galectin-1 and galectin-3 in intrahepatic cholangiocarcinoma.  |  Shimonishi, T., et al. 2001. Hum Pathol. 32: 302-10. PMID: 11274640
2. Isolation of a cDNA clone, encoding a human beta-galactoside binding protein, overexpressed during glucocorticoid-induced cell death.  |  Goldstone, SD. and Lavin, MF. 1991. Biochem Biophys Res Commun. 178: 746-50. PMID: 1713454
3. Galectin-1 links tumor hypoxia and radiotherapy.  |  Kuo, P. and Le, QT. 2014. Glycobiology. 24: 921-5. PMID: 24973253
4. Galectin-1 inhibitors and their potential therapeutic applications: a patent review.  |  Blanchard, H., et al. 2016. Expert Opin Ther Pat. 26: 537-54. PMID: 26950805
5. Evidence that the 14 kDa soluble beta-galactoside-binding lectin in man is encoded by a single gene.  |  Abbott, WM. and Feizi, T. 1989. Biochem J. 259: 291-4. PMID: 2719646
6. Cloning and nucleotide sequence of a full-length cDNA for human 14 kDa beta-galactoside-binding lectin.  |  Hirabayashi, J., et al. 1989. Biochim Biophys Acta. 1008: 85-91. PMID: 2719964
7. Molecular cloning, characterization, and expression of a human 14-kDa lectin.  |  Couraud, PO., et al. 1989. J Biol Chem. 264: 1310-6. PMID: 2910856
8. Therapeutic Potential of Galectin-1 and Galectin-3 in Autoimmune Diseases.  |  He, YS., et al. 2022. Curr Pharm Des. 28: 36-45. PMID: 34579628
9. Immunosuppressive Roles of Galectin-1 in the Tumor Microenvironment.  |  Huang, Y., et al. 2021. Biomolecules. 11: PMID: 34680031
10. Galectin-1-mediated MET/AXL signaling enhances sorafenib resistance in hepatocellular carcinoma by escaping ferroptosis.  |  Hsu, TW., et al. 2023. Aging (Albany NY). 15: 6503-6525. PMID: 37433225
11. Mapping on human and mouse chromosomes of the gene for the beta-galactoside-binding protein, an autocrine-negative growth factor.  |  Baldini, A., et al. 1993. Genomics. 15: 216-8. PMID: 8432540
12. Two members of the S-lac lectin gene family, LGALS1 and LGALS2, reside in close proximity on human chromosome 22q12-q13.  |  Mehrabian, M., et al. 1993. Genomics. 15: 418-20. PMID: 8449510

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-galectin-1 Antibody (C-8) has 26 citations in a variety of scientific publications.

Primary antibodies like Anti-galectin-1 Antibody (C-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

galectin-1 Antibody (C-8) Specifications

Alternate Product Name: galectin-1

Product Clone Name: C-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-45

Epitope Target: galectin-1

Epitope Species: human

Product Reactivity/Detection: galectin-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 26 citations in various scientific publications

Available Conjugates/Forms for galectin-1 Antibody (C-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin