GADD 45α Antibody (A-3): sc-515568
- GADD 45α Antibody (A-3) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 140-165 at the C-terminus of GADD 45α of human origin
- recommended for detection of GADD 45α of mouse, rat and human origin by WB, IP, IF and ELISA
- See GADD 45α (C-4): sc-6850 for GADD 45α antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GADD 45α Antibody (A-3) for WB applications. These reagents are now offered in bundles with GADD 45α Antibody (A-3) (see ordering information below).
GADD 45α Antibody (A-3) is a mouse monoclonal IgG2a antibody that detects GADD 45α in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GADD 45α plays a crucial role in the cellular response to DNA damage, acting as a mediator between the p53 tumor suppressor pathway and DNA repair mechanisms. GADD 45α interacts with cyclin-dependent kinases (Cdks) and proliferating cell nuclear antigen (PCNA), which are essential for cell cycle regulation and DNA replication. Through binding to these proteins, GADD 45α inhibits Cdk activity, preventing cell cycle progression while enhancing DNA excision repair processes. This dual functionality underscores GADD 45α′s importance in maintaining genomic stability and preventing tumorigenesis, making GADD 45α a vital target for research in cancer biology and therapeutic development. Anti-GADD 45α antibody (A-3) serves as an invaluable tool for scientists investigating cell cycle regulation and DNA repair pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GADD 45α Antibody (A-3) | sc-515568 | 200 µg/ml | $316.00 | |||
GADD 45α Antibody (A-3): m-IgG Fc BP-HRP Bundle | sc-538804 | 200 µg Ab; 10 µg BP | $354.00 | |||
GADD 45α Antibody (A-3): m-IgGκ BP-HRP Bundle | sc-536477 | 200 µg Ab; 40 µg BP | $354.00 | |||
GADD 45α Antibody (A-3): m-IgG2a BP-HRP Bundle | sc-548414 | 200 µg Ab; 10 µg BP | $354.00 | |||
GADD 45α (A-3) Neutralizing Peptide | sc-515568 P | 100 µg/0.5 ml | $68.00 |