GAD-65 Antibody (61/8F9): sc-130569
- GAD-65 Antibody (61/8F9) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against full-length recombinant GAD-65 of human origin, with epitope mapping to amino acids 4-17
- recommended for detection of GAD-65 of mouse, rat and human origin by WB, IP and IF; non cross-reactive with GAD-67
- See GAD-65 (A-3): sc-377145 for GAD-65 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GAD-65 Antibody (61/8F9). This work is in progress.
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GAD-65 Antibody (61/8F9) is a mouse monoclonal IgG1 antibody that detects glutamic acid decarboxylase 65 (GAD-65) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). GAD-65 plays a crucial role in the central nervous system as GAD-65 catalyzes the conversion of L-glutamic acid to gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the brain. This process is vital for maintaining the balance between excitation and inhibition in neuronal signaling, which is essential for proper brain function and preventing neurological disorders. Notably, GAD-65 is localized to synaptic vesicle membranes in nerve terminals, allowing for rapid GABA production in response to increased neuronal activity. In contrast, GAD-67, which is distributed throughout the cell, maintains basal GABA levels. The interplay between these two isoforms is critical; while the loss of GAD-65 can disrupt neurotransmission, the absence of GAD-67 is lethal, highlighting the importance of both proteins in neurophysiology. Anti-GAD-65 antibody (61/8F9) is an invaluable tool for researchers studying GABAergic signaling and its implications in various neurological conditions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GAD-65 Antibody (61/8F9) | sc-130569 | 200 µg/ml | $316.00 |