GABA_B R1 Antibody (D-2): sc-166408

GABAB R1 Antibody (D-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects GABAB R1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GABAB R1 (D-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GABAB R1 protein is a critical component of the GABAB receptor, which is a metabotropic receptor that plays a vital role in the central nervous system by mediating slow inhibitory neurotransmission. This receptor is a heterodimer composed of GABAB R1 and GABAB R2 subunits, both of which are predominantly expressed in the brain. GABAB receptor′s ability to modulate synaptic transmission is essential for various physiological processes, including muscle tone regulation, pain pathway modulation, and facilitation of long-term potentiation in the hippocampus, which is crucial for learning and memory. Additionally, GABAB R1 undergoes post-translational modifications, such as glycosylation, which are important for proper folding, stability, and function. These modifications can influence receptor trafficking and signaling, thereby impacting GABAergic neurotransmission efficacy. Understanding GABAB R1 dynamics and interactions is essential for developing therapeutic strategies targeting neurological disorders associated with GABA signaling dysregulation.

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GABA_B R1 Antibody (D-2) References:

1. Heteromeric assembly of GABA(B)R1 and GABA(B)R2 receptor subunits inhibits Ca(2+) current in sympathetic neurons.  |  Filippov, AK., et al. 2000. J Neurosci. 20: 2867-74. PMID: 10751439
2. The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx.  |  White, JH., et al. 2000. Proc Natl Acad Sci U S A. 97: 13967-72. PMID: 11087824
3. GABAB receptor subunits, R1 and R2, in brainstem catecholamine and serotonin neurons.  |  Burman, KJ., et al. 2003. Brain Res. 970: 35-46. PMID: 12706246
4. Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking.  |  Balasubramanian, S., et al. 2004. J Biol Chem. 279: 18840-50. PMID: 14966130
5. Assembly-dependent surface targeting of the heterodimeric GABAB Receptor is controlled by COPI but not 14-3-3.  |  Brock, C., et al. 2005. Mol Biol Cell. 16: 5572-8. PMID: 16176975
6. Functional expression of the GABAB receptor in human airway smooth muscle.  |  Osawa, Y., et al. 2006. Am J Physiol Lung Cell Mol Physiol. 291: L923-31. PMID: 16829628
7. GABAB receptor association with the PDZ scaffold Mupp1 alters receptor stability and function.  |  Balasubramanian, S., et al. 2007. J Biol Chem. 282: 4162-71. PMID: 17145756
8. Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons.  |  Chang, W., et al. 2007. J Biol Chem. 282: 25030-40. PMID: 17591780
9. GABA B receptor is a novel drug target for pancreatic cancer.  |  Schuller, HM., et al. 2008. Cancer. 112: 767-78. PMID: 18098271
10. GABABR1 (G1465A) gene variation and temporal lobe epilepsy controversy: new evidence.  |  Kauffman, MA., et al. 2008. Seizure. 17: 567-71. PMID: 18255321
11. Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study.  |  Agrawal, A., et al. 2008. Addiction. 103: 1027-38. PMID: 18482426
12. Positive regulation by GABA(B)R1 subunit of leptin expression through gene transactivation in adipocytes.  |  Nakamura, Y., et al. 2011. PLoS One. 6: e20167. PMID: 21655283

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GABA_B R1 Antibody (D-2) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-GABA_B R1 Antibody (D-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GABA_B R1 Antibody (D-2) Specifications

Alternate Product Name: GABBR1

Product Clone Name: D-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 929-958

Epitope Target: GABA_B R1

Epitope Species: rat

Product Reactivity/Detection: GABA_B R1α and GABA_B R1β

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for GABA_B R1 Antibody (D-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin