Date published: 2026-5-2

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GABAB R1 Activators

Santa Cruz Biotechnology now offers a broad range of GABA B R1 Activators for use in various applications. GABA B receptors, particularly those involving the R1 subunit, are metabotropic receptors that play a crucial role in inhibitory neurotransmission within the central nervous system. Unlike ionotropic GABA A receptors, GABA B receptors are G-protein-coupled and modulate synaptic activity through slower, longer-lasting effects. GABA B R1 Activators are essential tools in scientific research, enabling researchers to explore the specific roles of these receptors in modulating synaptic transmission, neural excitability, and neuroplasticity. By activating GABA B R1, scientists can investigate how these receptors influence various physiological processes, including pain perception, motor control, and the regulation of neurotransmitter release. These activators are widely used in neurophysiological studies, behavioral research, and pharmacological experiments to understand the broader implications of GABA B receptor activity in brain function and behavior. Additionally, GABA B R1 Activators are valuable for studying the interactions between GABA B receptors and other signaling pathways, providing insights into the complex regulatory mechanisms that maintain neural homeostasis. The availability of these activators has significantly advanced research in neurobiology and neuroscience, offering critical tools for dissecting the intricate dynamics of inhibitory signaling and its impact on overall brain function. View detailed information on our available GABA B R1 Activators by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Acamprosate Calcium

77337-73-6sc-210733
100 mg
$140.00
2
(0)

Acamprosate Calcium functions as a modulator of GABAB R1 receptors, exhibiting unique electrostatic interactions that facilitate receptor activation. Its distinct molecular structure allows for specific binding, influencing downstream signaling cascades. The compound's kinetic behavior reveals a slow dissociation rate from the receptor, promoting sustained activity. Additionally, its solubility characteristics enhance its distribution in biological systems, affecting overall receptor engagement and cellular response.

(±)-Baclofen

1134-47-0sc-200464
sc-200464A
1 g
5 g
$56.00
$258.00
(1)

Agonist of GABAB receptors, including GABAB R1, that mimics the effects of GABA, indirectly activating the receptor and modulating neurotransmission.

CGP 7930

57717-80-3sc-203543
sc-203543A
10 mg
50 mg
$155.00
$625.00
(0)

Positive allosteric modulator of GABAB receptors, enhancing the response to endogenous GABA and indirectly facilitating GABAB R1 activation.

Vigabatrin

60643-86-9sc-204382
sc-204382A
sc-204382B
sc-204382C
10 mg
50 mg
100 mg
1 g
$125.00
$485.00
$650.00
$1015.00
2
(1)

GABA transaminase inhibitor that indirectly increases GABA levels in the brain, subsequently enhancing GABAB R1 activation by endogenous GABA.

Valproic Acid

99-66-1sc-213144
10 g
$87.00
9
(1)

Enhances GABAergic neurotransmission by inhibiting GABA degradation and indirectly affecting GABAB R1 signaling.

Gabapentin

60142-96-3sc-201481
sc-201481A
sc-201481B
20 mg
100 mg
1 g
$53.00
$94.00
$135.00
7
(1)

Modulates GABAergic signaling, potentially impacting GABAB R1 activity, although its precise mechanism is not fully elucidated.

Muscimol

2763-96-4sc-200460
sc-200460A
5 mg
25 mg
$161.00
$537.00
2
(1)

Agonist of GABAA receptors, which can indirectly influence GABAB R1 activity through crosstalk between GABA receptor subtypes.