Gab 3 Antibody (F-1): sc-376456
- Gab 3 Antibody (F-1) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 227-263 within an internal region of Gab 3 of human origin
- Anti-Gab 3 Antibody (F-1) is recommended for detection of Gab 3 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Gab 3 Antibody (F-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Gab 3 Antibody (F-1). This work is in progress.
QUICK LINKS
Gab 3 Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Gab 3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gab 3 (F-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Gab (GRB2-associated binder)/DOS family of adaptor proteins, which includes Gab 3, plays a pivotal role in cellular signaling by acting as molecular scaffolds that facilitate protein recruitment to receptor tyrosine kinases (RTKs). Such recruitment is essential for propagating signaling cascades initiated by cytokine and growth factor interactions with RTKs, ultimately leading to cellular responses such as activation, proliferation, and differentiation. Gab 3 contains pleckstrin homology domains and potential binding sites for SH2 and SH3 domain-containing proteins, which are crucial for phosphorylation-dependent recruitment of signaling partners. The human Gab3 gene, located on chromosome Xq28, encodes a 586 amino acid protein that is integral to insulin receptor and epidermal growth factor receptor signaling pathways, underscoring Gab 3′s significance in mediating cellular responses to extracellular stimuli.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gab 3 Antibody (F-1) | sc-376456 | 200 µg/ml | $322.00 | |||
Gab 3 Antibody (F-1) AC | sc-376456 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Gab 3 Antibody (F-1) HRP | sc-376456 HRP | 200 µg/ml | $322.00 | |||
Gab 3 Antibody (F-1) FITC | sc-376456 FITC | 200 µg/ml | $336.00 | |||
Gab 3 Antibody (F-1) PE | sc-376456 PE | 200 µg/ml | $349.00 | |||
Gab 3 Antibody (F-1) Alexa Fluor® 488 | sc-376456 AF488 | 200 µg/ml | $364.00 | |||
Gab 3 Antibody (F-1) Alexa Fluor® 546 | sc-376456 AF546 | 200 µg/ml | $364.00 | |||
Gab 3 Antibody (F-1) Alexa Fluor® 594 | sc-376456 AF594 | 200 µg/ml | $364.00 | |||
Gab 3 Antibody (F-1) Alexa Fluor® 647 | sc-376456 AF647 | 200 µg/ml | $364.00 | |||
Gab 3 Antibody (F-1) Alexa Fluor® 680 | sc-376456 AF680 | 200 µg/ml | $364.00 | |||
Gab 3 Antibody (F-1) Alexa Fluor® 790 | sc-376456 AF790 | 200 µg/ml | $364.00 | |||
Gab 3 (F-1) Neutralizing Peptide | sc-376456 P | 100 µg/0.5 ml | $69.00 |