Gab 2 Antibody (H-6): sc-365590
- Gab 2 Antibody (H-6) is a mouse monoclonal IgG1 κ Gab 2 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 121-320 mapping near the N-terminus of Gab 2 of human origin
- Gab 2 Antibody (H-6) is recommended for detection of Gab 2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Gab 2 Antibody (H-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Gab 2 Antibody (H-6) for WB applications. These reagents are now offered in bundles with Gab 2 Antibody (H-6) (see ordering information below).
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Gab 2 Antibody (H-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Gab 2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gab 2 (H-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Gab 2 protein plays a crucial role in cellular signaling pathways, particularly in growth factor receptor activation. Gab 2 functions as an adapter protein that facilitates signal transmission from activated receptor tyrosine kinases to downstream signaling molecules, influencing cellular responses such as proliferation and differentiation. Gab 2 interacts with SH2 domain-containing proteins, including SHP2, which is essential for mediating cytokine-induced gene activation. Such interaction links extracellular signals to intracellular responses, making Gab 2 vital for regulating various biological processes. Gab 2′s ability to form complexes with other signaling proteins orchestrates complex signaling networks, critical for maintaining cellular homeostasis and responding to environmental cues.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Gab 2 Antibody (H-6) References:
- Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases. | McGlade, J., et al. 1992. Proc Natl Acad Sci U S A. 89: 8869-73. PMID: 1409579
- A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. | Pelicci, G., et al. 1992. Cell. 70: 93-104. PMID: 1623525
- Structure and function of Gab2 and its role in cancer (Review). | Ding, CB., et al. 2015. Mol Med Rep. 12: 4007-4014. PMID: 26095858
- The Gab2-MALT1 axis regulates thromboinflammation and deep vein thrombosis. | Kondreddy, V., et al. 2022. Blood. 140: 1549-1564. PMID: 35895897
- Gab2 plays a carcinogenic role in ovarian cancer by regulating CrkII. | Yin, Y., et al. 2023. J Ovarian Res. 16: 79. PMID: 37085900
- An analysis of the role of GAB2 in pan-cancer from a multidimensional perspective. | Yin, Y., et al. 2024. Discov Oncol. 15: 278. PMID: 38995439
- Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. | Araki, E., et al. 1994. Nature. 372: 186-90. PMID: 7526222
- Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. | Tamemoto, H., et al. 1994. Nature. 372: 182-6. PMID: 7969452
- Role of IRS-1-GRB-2 complexes in insulin signaling. | Myers, MG., et al. 1994. Mol Cell Biol. 14: 3577-87. PMID: 8196603
- Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation. | Ravichandran, KS., et al. 1993. Science. 262: 902-5. PMID: 8235613
- Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. | Lee, CH., et al. 1993. Proc Natl Acad Sci U S A. 90: 11713-7. PMID: 8265614
- Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation. | Gu, H., et al. 1998. Mol Cell. 2: 729-40. PMID: 9885561
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gab 2 Antibody (H-6) | sc-365590 | 200 µg/ml | $322.00 | |||
Gab 2 Antibody (H-6): m-IgG Fc BP-HRP Bundle | sc-529398 | 200 µg Ab; 10 µg BP | $361.00 | |||
Gab 2 Antibody (H-6): m-IgGκ BP-HRP Bundle | sc-522278 | 200 µg Ab, 40 µg BP | $361.00 | |||
Gab 2 Antibody (H-6): m-IgG1 BP-HRP Bundle | sc-543499 | 200 µg Ab; 20 µg BP | $361.00 | |||
Gab 2 Antibody (H-6) AC | sc-365590 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Gab 2 Antibody (H-6) HRP | sc-365590 HRP | 200 µg/ml | $322.00 | |||
Gab 2 Antibody (H-6) FITC | sc-365590 FITC | 200 µg/ml | $336.00 | |||
Gab 2 Antibody (H-6) PE | sc-365590 PE | 200 µg/ml | $349.00 | |||
Gab 2 Antibody (H-6) Alexa Fluor® 488 | sc-365590 AF488 | 200 µg/ml | $364.00 | |||
Gab 2 Antibody (H-6) Alexa Fluor® 546 | sc-365590 AF546 | 200 µg/ml | $364.00 | |||
Gab 2 Antibody (H-6) Alexa Fluor® 594 | sc-365590 AF594 | 200 µg/ml | $364.00 | |||
Gab 2 Antibody (H-6) Alexa Fluor® 647 | sc-365590 AF647 | 200 µg/ml | $364.00 | |||
Gab 2 Antibody (H-6) Alexa Fluor® 680 | sc-365590 AF680 | 200 µg/ml | $364.00 | |||
Gab 2 Antibody (H-6) Alexa Fluor® 790 | sc-365590 AF790 | 200 µg/ml | $364.00 |