Gab 1 Antibody (H-7): sc-133191

Gab 1 Antibody (H-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects Gab 1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Gab 1 (H-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Gab 1, also known as Growth Factor Receptor Bound Protein 2-Associated Protein 1, plays a crucial role in cellular signaling pathways, particularly in growth factor receptor activation. Gab 1 functions as an adapter protein that facilitates signal transmission from activated receptor tyrosine kinases to downstream signaling molecules, influencing cellular responses such as proliferation and differentiation. Gab 1 is essential in epidermal growth factor receptor (EGFR) and insulin receptor signaling pathways, where Gab 1 forms complexes with other adapter proteins like GRB2 and Sos, linking these receptors to the Ras signaling pathway. This interaction regulates various cellular processes, including metabolism and cell growth, making Gab 1 crucial for maintaining cellular homeostasis and responding to external growth signals.

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Gab 1 Antibody (H-7) References:

1. Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.  |  McGlade, J., et al. 1992. Proc Natl Acad Sci U S A. 89: 8869-73. PMID: 1409579
2. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.  |  Pelicci, G., et al. 1992. Cell. 70: 93-104. PMID: 1623525
3. Essential roles of Gab1 tyrosine phosphorylation in growth factor-mediated signaling and angiogenesis.  |  Wang, W., et al. 2015. Int J Cardiol. 181: 180-4. PMID: 25528308
4. Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation.  |  Xu, J., et al. 2023. JCI Insight. 8: PMID: 36795486
5. The Role of GAB1 in Cancer.  |  Pérez-Baena, MJ., et al. 2023. Cancers (Basel). 15: PMID: 37627207
6. Dysregulated Gab1 signalling in triple negative breast cancer.  |  Bongartz, H., et al. 2024. Cell Commun Signal. 22: 161. PMID: 38448989
7. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.  |  Araki, E., et al. 1994. Nature. 372: 186-90. PMID: 7526222
8. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.  |  Tamemoto, H., et al. 1994. Nature. 372: 182-6. PMID: 7969452
9. Role of IRS-1-GRB-2 complexes in insulin signaling.  |  Myers, MG., et al. 1994. Mol Cell Biol. 14: 3577-87. PMID: 8196603
10. Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation.  |  Ravichandran, KS., et al. 1993. Science. 262: 902-5. PMID: 8235613
11. Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells.  |  Lee, CH., et al. 1993. Proc Natl Acad Sci U S A. 90: 11713-7. PMID: 8265614
12. A Grb2-associated docking protein in EGF- and insulin-receptor signalling.  |  Holgado-Madruga, M., et al. 1996. Nature. 379: 560-4. PMID: 8596638

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Gab 1 Antibody (H-7) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-Gab 1 Antibody (H-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Gab 1 Antibody (H-7) Specifications

Alternate Product Name: GRB2 Associated Binding Protein 1

Product Clone Name: H-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 119-316

Epitope Target: Gab 1

Epitope Species: human

Product Reactivity/Detection: Gab 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for Gab 1 Antibody (H-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin